| Career - Wins | |||
| Rk | Player Name | Totals | |
| 1 | Max Scherzer | 150 | |
| 2 | Madison Bumgarner | 116 | |
| 3 | Mark Langston | 93 | |
| 4 | Chuck Finley | 77 | |
| 5 | Jacob deGrom | 75 | |
| 6 | Randy Johnson | 69 | |
| 7 | Chris Carpenter | 46 | |
| 8 | Curt Schilling | 44 | |
| 9 | Robbie Ray | 39 | |
| 10 | Charlie Hough | 37 | |
| 11 | Mike Moore | 31 | |
| 12 | Mike Remlinger | 30 | |
| 13 | Jason Schmidt | 28 | |
| 14 | Jose Quintana | 28 | |
| 15 | Kyle Gibson | 27 | |
| 16 | Pedro Astacio | 26 | |
| 17 | Steve Reed | 26 | |
| 18 | Ross Detwiler | 26 | |
| 19 | Pat Rapp | 25 | |
| 20 | Zack Greinke | 25 | |
| 21 | Carlos Rodon | 25 | |
| 22 | Shaun Marcum | 24 | |
| 23 | Kevin Appier | 23 | |
| 24 | Alan Benes | 23 | |
| 25 | Andy Pettitte | 23 | |
| Single Season - Wins | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Mark Langston | 22 | 1994 | ||
| 2 | Curt Schilling | 21 | 2003 | ||
| 3 | Randy Johnson | 19 | 2005 | ||
| 4 | Randy Johnson | 18 | 2001 | ||
| 5 | Armando Reynoso | 18 | 1994 | ||
| 6 | Curt Schilling | 18 | 2005 | ||
| 7 | Madison Bumgarner | 18 | 2015 | ||
| 8 | Max Scherzer | 18 | 2023 | ||
| 9 | Chuck Finley | 17 | 1994 | ||
| 10 | Max Scherzer | 17 | 2019 | ||
| 11 | Chris Carpenter | 16 | 2011 | ||
| 12 | Madison Bumgarner | 16 | 2018 | ||
| 13 | Max Scherzer | 16 | 2018 | ||
| 14 | Jacob deGrom | 16 | 2019 | ||
| 15 | Jose Quintana | 16 | 2023 | ||
| 16 | Charlie Hough | 15 | 1991 | ||
| 17 | Randy Johnson | 15 | 2002 | ||
| 18 | Mark Langston | 15 | 1993 | ||
| 19 | Pat Rapp | 15 | 1996 | ||
| 20 | Max Scherzer | 15 | 2014 | ||
| 21 | Max Scherzer | 15 | 2015 | ||
| 22 | Carlos Rodon | 15 | 2023 | ||
| 23 | Chuck Finley | 14 | 1998 | ||
| 24 | Butch Henry | 14 | 1996 | ||
| 25 | Brian Holman | 14 | 1991 | ||