| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Max Scherzer | 406 | |
| 2 | Madison Bumgarner | 362 | |
| 3 | Mark Langston | 260 | |
| 4 | Chuck Finley | 234 | |
| 5 | Jacob deGrom | 183 | |
| 6 | Randy Johnson | 165 | |
| 7 | Robbie Ray | 141 | |
| 8 | Chris Carpenter | 115 | |
| 9 | Charlie Hough | 114 | |
| 10 | Kyle Gibson | 107 | |
| 11 | Curt Schilling | 103 | |
| 12 | Mike Moore | 101 | |
| 13 | Jason Schmidt | 93 | |
| 14 | Pedro Astacio | 81 | |
| 15 | Shaun Marcum | 79 | |
| 16 | Brian Holman | 78 | |
| 17 | Aaron Harang | 75 | |
| 18 | Aaron Cook | 72 | |
| 19 | Zack Greinke | 72 | |
| 20 | Andy Pettitte | 72 | |
| 21 | Carlos Rodon | 72 | |
| 22 | Kevin Appier | 71 | |
| 23 | Pat Rapp | 71 | |
| 24 | Armando Reynoso | 70 | |
| 25 | Alex Wood | 66 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Charlie Hough | 47 | 1991 | ||
| 2 | Mark Langston | 44 | 1990 | ||
| 3 | Mark Langston | 43 | 1991 | ||
| 4 | Brian Holman | 42 | 1991 | ||
| 5 | Bobby Ojeda | 41 | 1990 | ||
| 6 | Fernando Valenzuela | 39 | 1990 | ||
| 7 | Armando Reynoso | 37 | 1994 | ||
| 8 | Chuck Finley | 36 | 1994 | ||
| 9 | Brian Holman | 36 | 1990 | ||
| 10 | Randy Johnson | 36 | 2001 | ||
| 11 | Mark Langston | 36 | 1992 | ||
| 12 | Mark Langston | 36 | 1993 | ||
| 13 | Mark Langston | 36 | 1994 | ||
| 14 | Mike Moore | 36 | 1992 | ||
| 15 | Curt Schilling | 36 | 2005 | ||
| 16 | Jason Schmidt | 36 | 2004 | ||
| 17 | Ryan Vogelsong | 36 | 2013 | ||
| 18 | Kyle Gibson | 36 | 2024 | ||
| 19 | Max Scherzer | 36 | 2024 | ||
| 20 | Greg W. Harris | 35 | 1994 | ||
| 21 | Charlie Hough | 35 | 1993 | ||
| 22 | Randy Johnson | 35 | 2005 | ||
| 23 | Russ Ortiz | 35 | 2000 | ||
| 24 | Bronson Arroyo | 35 | 2008 | ||
| 25 | Ricky Nolasco | 35 | 2009 | ||