| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Madison Bumgarner | 1258 | |
| 2 | Max Scherzer | 1186 | |
| 3 | Randy Johnson | 521 | |
| 4 | Jacob deGrom | 455 | |
| 5 | Robbie Ray | 444 | |
| 6 | Chris Carpenter | 408 | |
| 7 | Kyle Gibson | 360 | |
| 8 | Curt Schilling | 335 | |
| 9 | Jason Schmidt | 322 | |
| 10 | Aaron Harang | 313 | |
| 11 | Aaron Cook | 291 | |
| 12 | Pedro Astacio | 279 | |
| 13 | Shaun Marcum | 265 | |
| 14 | Alex Wood | 265 | |
| 15 | Kevin Appier | 264 | |
| 16 | Zack Greinke | 264 | |
| 17 | Chuck Finley | 254 | |
| 18 | Ryan Vogelsong | 232 | |
| 19 | Andy Pettitte | 226 | |
| 20 | Nate Robertson | 222 | |
| 21 | Carlos Rodon | 221 | |
| 22 | Alan Benes | 215 | |
| 23 | Hyun-Jin Ryu | 204 | |
| 24 | Scott Erickson | 199 | |
| 25 | Russ Ortiz | 199 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Kyle Gibson | 148 | 2024 | ||
| 2 | Carlos Perez | 147 | 1998 | ||
| 3 | Bronson Arroyo | 141 | 2008 | ||
| 4 | James Baldwin | 140 | 1997 | ||
| 5 | Russ Ortiz | 137 | 2000 | ||
| 6 | Nick Blackburn | 135 | 2010 | ||
| 7 | Curt Schilling | 132 | 2004 | ||
| 8 | Zack Greinke | 131 | 2009 | ||
| 9 | Chuck Finley | 130 | 1997 | ||
| 10 | Justin Dunn | 130 | 2021 | ||
| 11 | Scott Erickson | 129 | 2000 | ||
| 12 | Max Scherzer | 129 | 2013 | ||
| 13 | Jason Schmidt | 127 | 2004 | ||
| 14 | Kevin Appier | 125 | 2002 | ||
| 15 | Ricky Nolasco | 125 | 2009 | ||
| 16 | Alex Wood | 125 | 2018 | ||
| 17 | Chuck Finley | 124 | 1998 | ||
| 18 | Ryan Vogelsong | 124 | 2013 | ||
| 19 | Aaron Cook | 123 | 2011 | ||
| 20 | Randy Johnson | 122 | 2001 | ||
| 21 | Nate Robertson | 120 | 2007 | ||
| 22 | Chris Carpenter | 120 | 2012 | ||
| 23 | Madison Bumgarner | 120 | 2013 | ||
| 24 | Madison Bumgarner | 120 | 2020 | ||
| 25 | Randy Johnson | 119 | 2003 | ||