| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Max Scherzer | 2619.6 | |
| 2 | Madison Bumgarner | 2311.5 | |
| 3 | Mark Langston | 1726.7 | |
| 4 | Chuck Finley | 1535.7 | |
| 5 | Jacob deGrom | 1181.7 | |
| 6 | Randy Johnson | 1159.5 | |
| 7 | Charlie Hough | 906.0 | |
| 8 | Chris Carpenter | 756.8 | |
| 9 | Robbie Ray | 736.7 | |
| 10 | Curt Schilling | 732.0 | |
| 11 | Mike Moore | 630.0 | |
| 12 | Kyle Gibson | 617.7 | |
| 13 | Jason Schmidt | 566.0 | |
| 14 | Pedro Astacio | 515.7 | |
| 15 | Brian Holman | 490.3 | |
| 16 | Shaun Marcum | 462.4 | |
| 17 | Steve Reed | 456.4 | |
| 18 | Carlos Rodon | 450.3 | |
| 19 | Andy Pettitte | 442.3 | |
| 20 | Zack Greinke | 429.5 | |
| 21 | Alex Wood | 423.4 | |
| 22 | Mike Remlinger | 420.5 | |
| 23 | Aaron Harang | 419.6 | |
| 24 | Armando Reynoso | 406.0 | |
| 25 | Pat Rapp | 404.0 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Charlie Hough | 313.0 | 1991 | ||
| 2 | Mark Langston | 301.0 | 1990 | ||
| 3 | Mark Langston | 289.0 | 1994 | ||
| 4 | Brian Holman | 288.0 | 1991 | ||
| 5 | Mark Langston | 273.0 | 1993 | ||
| 6 | Mark Langston | 271.0 | 1991 | ||
| 7 | Curt Schilling | 267.0 | 2003 | ||
| 8 | Randy Johnson | 266.3 | 2001 | ||
| 9 | Charlie Hough | 262.3 | 1993 | ||
| 10 | Chuck Finley | 259.7 | 1994 | ||
| 11 | Chuck Finley | 259.3 | 1993 | ||
| 12 | Max Scherzer | 257.2 | 2016 | ||
| 13 | Armando Reynoso | 255.7 | 1994 | ||
| 14 | Randy Johnson | 255.3 | 2005 | ||
| 15 | Curt Schilling | 253.7 | 2005 | ||
| 16 | Bobby Ojeda | 253.3 | 1990 | ||
| 17 | Greg W. Harris | 247.7 | 1994 | ||
| 18 | Mark Langston | 246.0 | 1992 | ||
| 19 | Mike Moore | 239.3 | 1992 | ||
| 20 | Madison Bumgarner | 237.1 | 2017 | ||
| 21 | Max Scherzer | 236.1 | 2019 | ||
| 22 | Randy Johnson | 235.0 | 2003 | ||
| 23 | Jason Schmidt | 234.3 | 2004 | ||
| 24 | Chris Carpenter | 230.1 | 2010 | ||
| 25 | Madison Bumgarner | 229.1 | 2015 | ||