| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Adam Jones | 760 | |
| 2 | Frank Thomas | 749 | |
| 3 | Nolan Arenado | 710 | |
| 4 | Victor Martinez | 657 | |
| 5 | Hideki Matsui | 597 | |
| 6 | Edgar Martinez | 487 | |
| 7 | Paul O'Neill | 487 | |
| 8 | John Olerud | 423 | |
| 9 | Prince Fielder | 415 | |
| 10 | Eric Davis | 402 | |
| 11 | Marquis Grissom | 377 | |
| 12 | Vinny Castilla | 364 | |
| 13 | Rusty Greer | 361 | |
| 14 | Alexei Ramirez | 348 | |
| 15 | Corey Hart | 313 | |
| 16 | Joey Cora | 303 | |
| 17 | Ichiro Suzuki | 293 | |
| 18 | Juan Pierre | 286 | |
| 19 | Bret Boone | 283 | |
| 20 | Cameron Maybin | 282 | |
| 21 | Brett Gardner | 278 | |
| 22 | Rich Aurilia | 273 | |
| 23 | Ivan Rodriguez | 260 | |
| 24 | Cedric Mullins | 260 | |
| 25 | Kurt Suzuki | 258 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Brett Gardner | 137 | 2020 | ||
| 2 | Eric Davis | 133 | 1991 | ||
| 3 | Eric Davis | 127 | 1990 | ||
| 4 | Bret Boone | 126 | 2004 | ||
| 5 | Nolan Arenado | 126 | 2020 | ||
| 6 | Joey Cora | 124 | 1998 | ||
| 7 | Rusty Greer | 122 | 1998 | ||
| 8 | Scott Fletcher | 121 | 1994 | ||
| 9 | Marquis Grissom | 121 | 1994 | ||
| 10 | Edgardo Alfonzo | 120 | 2001 | ||
| 11 | Todd Hundley | 119 | 2001 | ||
| 12 | Paul O'Neill | 116 | 1995 | ||
| 13 | Frank Thomas | 116 | 1991 | ||
| 14 | Adam Jones | 114 | 2012 | ||
| 15 | Frank Thomas | 113 | 1995 | ||
| 16 | Prince Fielder | 112 | 2012 | ||
| 17 | Frank Thomas | 111 | 1998 | ||
| 18 | Jeff Bagwell | 111 | 2000 | ||
| 19 | EDGAR MARTINEZ | 110 | 1996 | ||
| 20 | Nolan Arenado | 110 | 2018 | ||
| 21 | Cameron Maybin | 110 | 2020 | ||
| 22 | EDGAR MARTINEZ | 109 | 1998 | ||
| 23 | John Olerud | 109 | 2002 | ||
| 24 | Charlie Hayes | 108 | 1994 | ||
| 25 | Brad Komminsk | 108 | 1990 | ||