| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Shane Bieber | 636 | |
| 2 | Pablo Lopez | 587 | |
| 3 | Kevin Millwood | 526 | |
| 4 | Mike Leake | 525 | |
| 5 | Clayton Kershaw | 451 | |
| 6 | Matt Boyd | 397 | |
| 7 | Bartolo Colon | 383 | |
| 8 | James Shields | 361 | |
| 9 | Shawn Estes | 324 | |
| 10 | Kris Benson | 313 | |
| 11 | Chad Kuhl | 288 | |
| 12 | Brian Moehler | 261 | |
| 13 | Ted Lilly | 250 | |
| 14 | Mitch Keller | 237 | |
| 15 | Kelvim Escobar | 236 | |
| 16 | Jaret Wright | 230 | |
| 17 | Tommy Hanson | 230 | |
| 18 | Anibal Sanchez | 226 | |
| 19 | Diego Castillo | 219 | |
| 20 | Jaime Navarro | 211 | |
| 21 | Mike Hampton | 211 | |
| 22 | Zach Thompson | 209 | |
| 23 | Brad Radke | 206 | |
| 24 | Drew Rasmussen | 200 | |
| 25 | Doug Fister | 191 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Mike Leake | 169 | 2017 | ||
| 2 | Chad Kuhl | 149 | 2018 | ||
| 3 | Mitch Keller | 147 | 2020 | ||
| 4 | James Shields | 139 | 2007 | ||
| 5 | Kevin Millwood | 135 | 2003 | ||
| 6 | Jaret Wright | 133 | 1999 | ||
| 7 | Bartolo Colon | 133 | 1999 | ||
| 8 | Brad Radke | 132 | 1997 | ||
| 9 | Pablo Lopez | 131 | 2019 | ||
| 10 | Kevin Millwood | 130 | 2004 | ||
| 11 | Mike Hampton | 129 | 2000 | ||
| 12 | Bryan Rekar | 129 | 2001 | ||
| 13 | Ted Lilly | 129 | 2008 | ||
| 14 | Darren Oliver | 128 | 1998 | ||
| 15 | Chris Holt | 128 | 1998 | ||
| 16 | Tommy Hanson | 126 | 2010 | ||
| 17 | Shane Bieber | 125 | 2024 | ||
| 18 | Rich Hill | 124 | 2007 | ||
| 19 | Jonathon Niese | 124 | 2013 | ||
| 20 | Zach Neal | 123 | 2017 | ||
| 21 | Matt Boyd | 122 | 2020 | ||
| 22 | Kris Benson | 121 | 2005 | ||
| 23 | Brian Moehler | 121 | 1999 | ||
| 24 | Ted Lilly | 121 | 2007 | ||
| 25 | Tony Armas | 120 | 2002 | ||