| Career - At Bats | |||
| Rk | Player Name | Totals | |
| 1 | Vladimir Guerrero | 6539 | |
| 2 | Carlos Santana | 4584 | |
| 3 | Andrew McCutchen | 4501 | |
| 4 | Wade Boggs | 4267 | |
| 5 | Jay Buhner | 3696 | |
| 6 | Juan Soto | 3393 | |
| 7 | Yoan Moncada | 3347 | |
| 8 | Hal Morris | 3263 | |
| 9 | Delino DeShields | 3195 | |
| 10 | Placido Polanco | 3106 | |
| 11 | Andres Galarraga | 2860 | |
| 12 | Mike Piazza | 2822 | |
| 13 | Bernie Williams | 2710 | |
| 14 | Troy Glaus | 2678 | |
| 15 | J.P. Crawford | 2505 | |
| 16 | Fernando Tatis | 2293 | |
| 17 | Alex Rodriguez | 2287 | |
| 18 | Chad Curtis | 2159 | |
| 19 | Cavan Biggio | 2126 | |
| 20 | Mike Stanley | 2062 | |
| 21 | Sean Murphy | 1977 | |
| 22 | Joe Mauer | 1902 | |
| 23 | Jeff Blauser | 1759 | |
| 24 | Omar Narvaez | 1759 | |
| 25 | Eric Hosmer | 1733 | |
| Single Season - At Bats | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Vladimir Guerrero | 700 | 2000 | ||
| 2 | Willie McGee | 698 | 1991 | ||
| 3 | Vladimir Guerrero | 685 | 2006 | ||
| 4 | Vladimir Guerrero | 683 | 2001 | ||
| 5 | Andrew McCutchen | 678 | 2010 | ||
| 6 | Yoan Moncada | 677 | 2020 | ||
| 7 | Andrew McCutchen | 676 | 2013 | ||
| 8 | Robin Yount | 669 | 1990 | ||
| 9 | Chris Coghlan | 669 | 2015 | ||
| 10 | Alex Rodriguez | 667 | 1999 | ||
| 11 | J.P. Crawford | 664 | 2022 | ||
| 12 | Vladimir Guerrero | 661 | 2007 | ||
| 13 | Andrew McCutchen | 661 | 2014 | ||
| 14 | Kevin Frandsen | 659 | 2013 | ||
| 15 | Delino DeShields | 657 | 1993 | ||
| 16 | Cesar Hernandez | 657 | 2017 | ||
| 17 | Vladimir Guerrero | 656 | 2003 | ||
| 18 | Ryan Theriot | 656 | 2007 | ||
| 19 | Tyler Naquin | 656 | 2017 | ||
| 20 | Vladimir Guerrero | 654 | 2002 | ||
| 21 | Tony Kemp | 654 | 2019 | ||
| 22 | Andres Galarraga | 653 | 1995 | ||
| 23 | Mike Stanley | 652 | 1994 | ||
| 24 | Alex Rodriguez | 651 | 2001 | ||
| 25 | Jay Buhner | 649 | 1994 | ||