| Career - Homeruns Allowed | |||
| Rk | Player Name | Totals | |
| 1 | Jack McDowell | 178 | |
| 2 | Shane Bieber | 176 | |
| 3 | Pablo Lopez | 171 | |
| 4 | Tom Candiotti | 151 | |
| 5 | Mike Leake | 127 | |
| 6 | Matt Boyd | 119 | |
| 7 | Brad Radke | 113 | |
| 8 | Kevin Millwood | 110 | |
| 9 | James Shields | 95 | |
| 10 | Bartolo Colon | 93 | |
| 11 | Kris Benson | 86 | |
| 12 | Mike Moore | 86 | |
| 13 | Clayton Kershaw | 86 | |
| 14 | Ted Lilly | 74 | |
| 15 | Chris Nabholz | 72 | |
| 16 | Bud Black | 66 | |
| 17 | Kelvim Escobar | 63 | |
| 18 | Trevor May | 62 | |
| 19 | Chad Kuhl | 61 | |
| 20 | Diego Castillo | 61 | |
| 21 | Curt Schilling | 60 | |
| 22 | Shawn Estes | 56 | |
| 23 | Jorge Alcala | 56 | |
| 24 | Brian Moehler | 55 | |
| 25 | Anibal Sanchez | 55 | |
| Single Season - Homeruns Allowed | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Kolby Allard | 52 | 2022 | ||
| 2 | Mike Moore | 51 | 1989 | ||
| 3 | Tom Candiotti | 50 | 1991 | ||
| 4 | Brad Radke | 48 | 1997 | ||
| 5 | James Shields | 45 | 2008 | ||
| 6 | Matt Boyd | 44 | 2020 | ||
| 7 | Pablo Lopez | 44 | 2022 | ||
| 8 | Jack McDowell | 43 | 1994 | ||
| 9 | Chris Nabholz | 41 | 1994 | ||
| 10 | Mike Leake | 41 | 2017 | ||
| 11 | Shane Bieber | 41 | 2020 | ||
| 12 | Curt Schilling | 39 | 2002 | ||
| 13 | Kris Benson | 39 | 2006 | ||
| 14 | Bud Black | 38 | 1991 | ||
| 15 | Ted Lilly | 38 | 2007 | ||
| 16 | Brad Radke | 37 | 1996 | ||
| 17 | Brian Moehler | 36 | 1999 | ||
| 18 | Ted Lilly | 36 | 2008 | ||
| 19 | Mike Moore | 35 | 1990 | ||
| 20 | Tanner Bibee | 35 | 2024 | ||
| 21 | Jack McDowell | 34 | 1991 | ||
| 22 | Shane Bieber | 34 | 2022 | ||
| 23 | Jose DeLeon | 33 | 1990 | ||
| 24 | Mike Hampton | 33 | 2000 | ||
| 25 | Shaun Marcum | 33 | 2008 | ||