| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Tom Candiotti | 1708.1 | |
| 2 | Jack McDowell | 1573.6 | |
| 3 | Clayton Kershaw | 1152.7 | |
| 4 | Shane Bieber | 1123.7 | |
| 5 | Pablo Lopez | 1123.7 | |
| 6 | Kevin Millwood | 999.7 | |
| 7 | Mike Leake | 933.1 | |
| 8 | Chris Nabholz | 690.0 | |
| 9 | Matt Boyd | 654.3 | |
| 10 | Bartolo Colon | 641.4 | |
| 11 | Drew Rasmussen | 559.5 | |
| 12 | Brad Radke | 555.0 | |
| 13 | Kris Benson | 551.6 | |
| 14 | James Shields | 542.5 | |
| 15 | Scott Sanders | 515.4 | |
| 16 | Bud Black | 499.0 | |
| 17 | Tanner Roark | 472.4 | |
| 18 | Mariano Rivera | 463.4 | |
| 19 | Kelvim Escobar | 450.5 | |
| 20 | Diego Castillo | 448.6 | |
| 21 | Randy Tomlin | 448.0 | |
| 22 | Brian Moehler | 424.3 | |
| 23 | Shawn Estes | 423.4 | |
| 24 | Tommy Hanson | 420.3 | |
| 25 | Michael Wacha | 416.3 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Dave Stewart | 331.3 | 1991 | ||
| 2 | Mike Moore | 327.3 | 1990 | ||
| 3 | Tom Candiotti | 313.7 | 1991 | ||
| 4 | Jack McDowell | 302.0 | 1993 | ||
| 5 | Jack McDowell | 301.0 | 1994 | ||
| 6 | Jose DeLeon | 297.7 | 1990 | ||
| 7 | Clayton Kershaw | 274.2 | 2014 | ||
| 8 | Tom Candiotti | 271.3 | 1992 | ||
| 9 | Bud Black | 268.3 | 1991 | ||
| 10 | Clayton Kershaw | 262.2 | 2013 | ||
| 11 | Chris Bosio | 259.7 | 1990 | ||
| 12 | Tom Candiotti | 256.3 | 1994 | ||
| 13 | Chris Nabholz | 254.3 | 1994 | ||
| 14 | Jack McDowell | 252.0 | 1992 | ||
| 15 | Curt Schilling | 251.3 | 2002 | ||
| 16 | Clayton Kershaw | 243.2 | 2015 | ||
| 17 | Brad Radke | 242.0 | 1997 | ||
| 18 | Ben Sheets | 241.1 | 2009 | ||
| 19 | Mike Hampton | 240.7 | 2000 | ||
| 20 | Kevin Millwood | 239.0 | 2006 | ||
| 21 | Mark Hendrickson | 237.3 | 2003 | ||
| 22 | Kevin Millwood | 237.3 | 2004 | ||
| 23 | Mike Leake | 236.0 | 2016 | ||
| 24 | Kevin Millwood | 233.3 | 2003 | ||
| 25 | Bud Black | 230.7 | 1990 | ||