| Career - Strikeouts | |||
| Rk | Player Name | Totals | |
| 1 | Yoan Moncada | 1183 | |
| 2 | Jay Buhner | 992 | |
| 3 | Andrew McCutchen | 943 | |
| 4 | Carlos Santana | 942 | |
| 5 | Vladimir Guerrero | 939 | |
| 6 | Juan Soto | 805 | |
| 7 | Troy Glaus | 776 | |
| 8 | Andres Galarraga | 714 | |
| 9 | Cavan Biggio | 696 | |
| 10 | Fernando Tatis | 683 | |
| 11 | Delino DeShields | 634 | |
| 12 | J.P. Crawford | 585 | |
| 13 | Sean Murphy | 581 | |
| 14 | Alex Rodriguez | 520 | |
| 15 | Bernie Williams | 454 | |
| 16 | Omar Narvaez | 441 | |
| 17 | Ryan Church | 432 | |
| 18 | Mike Stanley | 427 | |
| 19 | Mike Piazza | 422 | |
| 20 | Hal Morris | 391 | |
| 21 | Carlos Delgado | 389 | |
| 22 | Eric Hosmer | 379 | |
| 23 | Mark Bellhorn | 359 | |
| 24 | Chris Davis | 359 | |
| 25 | Jeff Blauser | 355 | |
| Single Season - Strikeouts | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Cecil Fielder | 256 | 1991 | ||
| 2 | Tyler Naquin | 234 | 2017 | ||
| 3 | Jesus Sanchez | 219 | 2022 | ||
| 4 | Yoan Moncada | 216 | 2020 | ||
| 5 | Jay Buhner | 211 | 1992 | ||
| 6 | J.D. Martinez | 211 | 2015 | ||
| 7 | Yoan Moncada | 209 | 2021 | ||
| 8 | Cavan Biggio | 204 | 2020 | ||
| 9 | Chris Davis | 202 | 2016 | ||
| 10 | Rodolfo Castro | 202 | 2023 | ||
| 11 | Yoan Moncada | 201 | 2022 | ||
| 12 | Nick Williams | 199 | 2018 | ||
| 13 | Fernando Tatis | 198 | 2022 | ||
| 14 | Fernando Tatis | 197 | 2021 | ||
| 15 | Troy Glaus | 196 | 2001 | ||
| 16 | Carlos Pena | 196 | 2010 | ||
| 17 | Mark Bellhorn | 194 | 2003 | ||
| 18 | Yoan Moncada | 188 | 2024 | ||
| 19 | Desmond Jennings | 184 | 2012 | ||
| 20 | Yoan Moncada | 184 | 2018 | ||
| 21 | Cavan Biggio | 184 | 2024 | ||
| 22 | Giancarlo Stanton | 181 | 2012 | ||
| 23 | Jared Walsh | 180 | 2022 | ||
| 24 | Brandon Moss | 179 | 2015 | ||
| 25 | Yoan Moncada | 178 | 2019 | ||