| Career - RBI | |||
| Rk | Player Name | Totals | |
| 1 | Vladimir Guerrero | 1244 | |
| 2 | Carlos Santana | 698 | |
| 3 | Andrew McCutchen | 658 | |
| 4 | Jay Buhner | 610 | |
| 5 | Juan Soto | 570 | |
| 6 | Andres Galarraga | 552 | |
| 7 | Troy Glaus | 484 | |
| 8 | Wade Boggs | 476 | |
| 9 | Mike Piazza | 470 | |
| 10 | Hal Morris | 449 | |
| 11 | Fernando Tatis | 437 | |
| 12 | Alex Rodriguez | 391 | |
| 13 | Yoan Moncada | 390 | |
| 14 | Mike Stanley | 354 | |
| 15 | Bernie Williams | 334 | |
| 16 | Carlos Delgado | 327 | |
| 17 | Sean Murphy | 309 | |
| 18 | Placido Polanco | 291 | |
| 19 | Joe Mauer | 290 | |
| 20 | J.P. Crawford | 269 | |
| 21 | Jared Walsh | 267 | |
| 22 | Delino DeShields | 261 | |
| 23 | Mike Sweeney | 259 | |
| 24 | Giancarlo Stanton | 258 | |
| 25 | Cavan Biggio | 257 | |
| Single Season - RBI | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Cecil Fielder | 224 | 1991 | ||
| 2 | Vladimir Guerrero | 166 | 2006 | ||
| 3 | Jared Walsh | 154 | 2021 | ||
| 4 | Andres Galarraga | 144 | 1995 | ||
| 5 | Vladimir Guerrero | 142 | 1999 | ||
| 6 | Andres Galarraga | 139 | 1994 | ||
| 7 | Vladimir Guerrero | 132 | 2003 | ||
| 8 | Mike Stanley | 131 | 1994 | ||
| 9 | Jay Buhner | 130 | 1994 | ||
| 10 | Fernando Tatis | 130 | 2021 | ||
| 11 | Ty Wigginton | 129 | 2003 | ||
| 12 | Carlos Delgado | 128 | 2000 | ||
| 13 | Barry Bonds | 127 | 2003 | ||
| 14 | Vladimir Guerrero | 127 | 2001 | ||
| 15 | Vladimir Guerrero | 127 | 2007 | ||
| 16 | Kal Daniels | 126 | 1991 | ||
| 17 | Juan Soto | 126 | 2021 | ||
| 18 | Justin Upton | 124 | 2012 | ||
| 19 | Fernando Tatis | 124 | 2022 | ||
| 20 | Richard Hidalgo | 122 | 2001 | ||
| 21 | Vladimir Guerrero | 122 | 2000 | ||
| 22 | Giancarlo Stanton | 121 | 2012 | ||
| 23 | Carlos Santana | 119 | 2020 | ||
| 24 | Vladimir Guerrero | 117 | 2002 | ||
| 25 | Josh Donaldson | 117 | 2014 | ||