| Career - Wins | |||
| Rk | Player Name | Totals | |
| 1 | Mike Mussina | 120 | |
| 2 | Barry Zito | 74 | |
| 3 | Tom Glavine | 67 | |
| 4 | Dwight Gooden | 56 | |
| 5 | Andy Pettitte | 49 | |
| 6 | Bruce Hurst | 46 | |
| 7 | David Wells | 40 | |
| 8 | John Burkett | 38 | |
| 9 | Cristian Javier | 37 | |
| 10 | Tom Koehler | 36 | |
| 11 | Livan Hernandez | 33 | |
| 12 | Koji Uehara | 33 | |
| 13 | Dinelson Lamet | 33 | |
| 14 | Mike Boddicker | 31 | |
| 15 | Jason Isringhausen | 30 | |
| 16 | Tommy Greene | 29 | |
| 17 | Darryl Kile | 28 | |
| 18 | Jeff Suppan | 28 | |
| 19 | Scott Baker | 28 | |
| 20 | Jeff Shaw | 27 | |
| 21 | Yu Darvish | 27 | |
| 22 | Colby Lewis | 26 | |
| 23 | Adam Eaton | 25 | |
| 24 | Kirk Rueter | 25 | |
| 25 | Michael Fiers | 25 | |
| Single Season - Wins | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Mike Boddicker | 21 | 1991 | ||
| 2 | Paul Byrd | 20 | 2003 | ||
| 3 | Mike Mussina | 18 | 2001 | ||
| 4 | Mike Mussina | 18 | 2003 | ||
| 5 | Dwight Gooden | 17 | 1991 | ||
| 6 | Scott Garrelts | 16 | 1990 | ||
| 7 | Dwight Gooden | 16 | 1993 | ||
| 8 | Tommy Greene | 16 | 1994 | ||
| 9 | Darryl Kile | 16 | 1994 | ||
| 10 | Rick Reuschel | 16 | 1990 | ||
| 11 | Barry Zito | 16 | 2001 | ||
| 12 | Barry Zito | 16 | 2004 | ||
| 13 | Mike Mussina | 16 | 2007 | ||
| 14 | Dinelson Lamet | 16 | 2021 | ||
| 15 | Bruce Hurst | 15 | 1990 | ||
| 16 | Bruce Hurst | 15 | 1991 | ||
| 17 | Barry Zito | 15 | 2002 | ||
| 18 | Andy Pettitte | 15 | 2006 | ||
| 19 | Mike Mussina | 14 | 1998 | ||
| 20 | John Burkett | 14 | 1998 | ||
| 21 | Mike Mussina | 14 | 1999 | ||
| 22 | Ismael Valdes | 14 | 1996 | ||
| 23 | William Van Landingham | 14 | 1995 | ||
| 24 | Allen Watson | 14 | 1997 | ||
| 25 | Barry Zito | 14 | 2003 | ||