| Career - ERA | |||
| Rk | Player Name | Totals | |
| 1 | Koji Uehara | 2.45 | |
| 2 | Darryl Kile | 3.53 | |
| 3 | Dwight Gooden | 3.56 | |
| 4 | Dinelson Lamet | 3.83 | |
| 5 | Bruce Hurst | 3.85 | |
| 6 | Yu Darvish | 3.94 | |
| 7 | Mike Mussina | 3.99 | |
| 8 | Jason Isringhausen | 4.00 | |
| 9 | Tommy Greene | 4.15 | |
| 10 | Marcus Stroman | 4.19 | |
| 11 | Barry Zito | 4.23 | |
| 12 | Colby Lewis | 4.42 | |
| 13 | Tom Koehler | 4.47 | |
| 14 | Kenta Maeda | 4.50 | |
| 15 | Cristian Javier | 4.50 | |
| 16 | Livan Hernandez | 4.58 | |
| 17 | Scott Baker | 4.58 | |
| 18 | Domingo German | 4.68 | |
| 19 | Tom Glavine | 4.71 | |
| 20 | Mike Boddicker | 4.81 | |
| 21 | David Wells | 4.91 | |
| 22 | John Burkett | 5.00 | |
| 23 | Andy Pettitte | 5.00 | |
| 24 | Jeff Suppan | 5.08 | |
| Single Season - ERA | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Ismael Valdes | 2.00 | 1996 | ||
| 2 | Dwight Gooden | 2.06 | 1993 | ||
| 3 | Bruce Hurst | 2.50 | 1992 | ||
| 4 | Mike Mussina | 2.65 | 1998 | ||
| 5 | Barry Zito | 2.72 | 2001 | ||
| 6 | Dwight Gooden | 2.89 | 1992 | ||
| 7 | Paul Byrd | 2.95 | 2003 | ||
| 8 | Tom Glavine | 2.96 | 1993 | ||
| 9 | Frank Castillo | 2.97 | 1992 | ||
| 10 | Bruce Hurst | 3.01 | 1993 | ||
| 11 | Dinelson Lamet | 3.16 | 2021 | ||
| 12 | Marcus Stroman | 3.19 | 2024 | ||
| 13 | Darryl Kile | 3.31 | 1994 | ||
| 14 | Mike Mussina | 3.34 | 2007 | ||
| 15 | Scott Garrelts | 3.38 | 1990 | ||
| 16 | Cristian Javier | 3.48 | 2023 | ||
| 17 | Chad Gaudin | 3.49 | 2014 | ||
| 18 | Dinelson Lamet | 3.51 | 2018 | ||
| 19 | Andy Pettitte | 3.53 | 2006 | ||
| 20 | Yu Darvish | 3.78 | 2013 | ||
| 21 | Tom Koehler | 3.80 | 2016 | ||
| 22 | Mike Mussina | 3.83 | 2000 | ||
| 23 | Ivan Nova | 3.83 | 2014 | ||
| 24 | Michael Fiers | 3.88 | 2016 | ||
| 25 | Mike Mussina | 3.89 | 2003 | ||