| Career - Strikeouts | |||
| Rk | Player Name | Totals | |
| 1 | Mike Mussina | 1780 | |
| 2 | Dwight Gooden | 835 | |
| 3 | Dinelson Lamet | 809 | |
| 4 | Barry Zito | 779 | |
| 5 | Cristian Javier | 772 | |
| 6 | Tom Glavine | 746 | |
| 7 | Bruce Hurst | 680 | |
| 8 | Koji Uehara | 670 | |
| 9 | Andy Pettitte | 649 | |
| 10 | Yu Darvish | 623 | |
| 11 | Kenta Maeda | 511 | |
| 12 | John Burkett | 486 | |
| 13 | Tom Koehler | 472 | |
| 14 | Domingo German | 464 | |
| 15 | David Wells | 458 | |
| 16 | Scott Baker | 457 | |
| 17 | Colby Lewis | 446 | |
| 18 | Marcus Stroman | 412 | |
| 19 | Livan Hernandez | 411 | |
| 20 | Mychal Givens | 407 | |
| 21 | Darryl Kile | 360 | |
| 22 | Michael Fiers | 341 | |
| 23 | Mike Boddicker | 340 | |
| 24 | Jeff Suppan | 340 | |
| 25 | Yonny Chirinos | 332 | |
| Single Season - Strikeouts | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Dinelson Lamet | 296 | 2021 | ||
| 2 | Dwight Gooden | 278 | 1991 | ||
| 3 | Cristian Javier | 263 | 2023 | ||
| 4 | Bruce Hurst | 256 | 1991 | ||
| 5 | Yu Darvish | 256 | 2013 | ||
| 6 | Yu Darvish | 252 | 2014 | ||
| 7 | Dinelson Lamet | 240 | 2018 | ||
| 8 | Mike Mussina | 236 | 2007 | ||
| 9 | Mike Mussina | 231 | 1998 | ||
| 10 | Mike Boddicker | 221 | 1991 | ||
| 11 | Cristian Javier | 221 | 2021 | ||
| 12 | Mike Mussina | 219 | 2002 | ||
| 13 | Mike Mussina | 215 | 2000 | ||
| 14 | Juan Guzman | 208 | 1994 | ||
| 15 | Cristian Javier | 207 | 2022 | ||
| 16 | Mike Mussina | 203 | 2003 | ||
| 17 | Colby Lewis | 202 | 2011 | ||
| 18 | Domingo German | 201 | 2024 | ||
| 19 | Barry Zito | 199 | 2002 | ||
| 20 | Dinelson Lamet | 199 | 2020 | ||
| 21 | Kenta Maeda | 198 | 2017 | ||
| 22 | Griffin Canning | 198 | 2024 | ||
| 23 | Mike Mussina | 196 | 2001 | ||
| 24 | Andy Pettitte | 195 | 2006 | ||
| 25 | Mike Mussina | 192 | 1999 | ||