| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Mike Mussina | 2079.0 | |
| 2 | Tom Glavine | 1323.7 | |
| 3 | Dwight Gooden | 1154.3 | |
| 4 | Bruce Hurst | 1104.7 | |
| 5 | Barry Zito | 1051.8 | |
| 6 | Andy Pettitte | 816.5 | |
| 7 | John Burkett | 767.2 | |
| 8 | David Wells | 759.0 | |
| 9 | Livan Hernandez | 673.8 | |
| 10 | Jeff Suppan | 648.3 | |
| 11 | Tom Koehler | 638.6 | |
| 12 | Cristian Javier | 635.5 | |
| 13 | Dinelson Lamet | 626.8 | |
| 14 | Scott Baker | 560.5 | |
| 15 | Koji Uehara | 551.6 | |
| 16 | Darryl Kile | 518.0 | |
| 17 | Yu Darvish | 513.4 | |
| 18 | Mike Boddicker | 511.3 | |
| 19 | Kenta Maeda | 497.5 | |
| 20 | Colby Lewis | 488.3 | |
| 21 | Domingo German | 486.4 | |
| 22 | Marcus Stroman | 474.4 | |
| 23 | Tommy Greene | 442.0 | |
| 24 | Jason Isringhausen | 407.0 | |
| 25 | Yonny Chirinos | 397.4 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Bruce Hurst | 341.3 | 1991 | ||
| 2 | Mike Boddicker | 333.0 | 1991 | ||
| 3 | Bruce Hurst | 320.7 | 1990 | ||
| 4 | Rick Reuschel | 302.7 | 1990 | ||
| 5 | Dwight Gooden | 291.0 | 1991 | ||
| 6 | Dwight Gooden | 275.7 | 1993 | ||
| 7 | Dwight Gooden | 262.0 | 1994 | ||
| 8 | Scott Garrelts | 260.7 | 1990 | ||
| 9 | Mike Mussina | 255.0 | 1998 | ||
| 10 | Mike Mussina | 254.0 | 2000 | ||
| 11 | Tom Glavine | 251.7 | 1992 | ||
| 12 | Mike Mussina | 248.0 | 2007 | ||
| 13 | Tom Glavine | 246.0 | 1993 | ||
| 14 | Paul Byrd | 241.3 | 2003 | ||
| 15 | Tommy Greene | 240.3 | 1994 | ||
| 16 | Juan Guzman | 240.0 | 1994 | ||
| 17 | Mike Mussina | 238.3 | 2003 | ||
| 18 | Andy Pettitte | 237.0 | 2006 | ||
| 19 | Mike Mussina | 235.0 | 2001 | ||
| 20 | Yu Darvish | 233.2 | 2013 | ||
| 21 | Mike Mussina | 231.0 | 2002 | ||
| 22 | Bruce Hurst | 230.7 | 1992 | ||
| 23 | Mike Mussina | 230.1 | 1999 | ||
| 24 | Dinelson Lamet | 228.2 | 2021 | ||
| 25 | Barry Zito | 227.7 | 2003 | ||