| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Yu Darvish | 697 | |
| 2 | Martin Perez | 589 | |
| 3 | Roy Halladay | 548 | |
| 4 | Brad Radke | 518 | |
| 5 | Shohei Ohtani | 433 | |
| 6 | Edwin Jackson | 423 | |
| 7 | Lance Lynn | 407 | |
| 8 | Joey Hamilton | 366 | |
| 9 | Matt Garza | 357 | |
| 10 | Daniel Norris | 348 | |
| 11 | Jaime Garcia | 325 | |
| 12 | Dustin Hermanson | 324 | |
| 13 | Jake Peavy | 322 | |
| 14 | Kyle Lohse | 321 | |
| 15 | Darryl Kile | 296 | |
| 16 | Javier Vazquez | 275 | |
| 17 | Bud Norris | 275 | |
| 18 | Corey Kluber | 274 | |
| 19 | Garrett Richards | 272 | |
| 20 | Matt Moore | 261 | |
| 21 | Trevor Williams | 256 | |
| 22 | Lance McCullers | 240 | |
| 23 | Andy Ashby | 226 | |
| 24 | Clayton Kershaw | 223 | |
| 25 | Wade Miley | 220 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | James Shields | 150 | 2019 | ||
| 2 | Joey Hamilton | 148 | 1999 | ||
| 3 | Lance Lynn | 143 | 2024 | ||
| 4 | Brad Penny | 141 | 2007 | ||
| 5 | Jason Schmidt | 139 | 1999 | ||
| 6 | Matt Garza | 138 | 2011 | ||
| 7 | Yu Darvish | 137 | 2022 | ||
| 8 | Tommy Hunter | 134 | 2011 | ||
| 9 | Brad Radke | 133 | 2001 | ||
| 10 | Jason Jennings | 133 | 2007 | ||
| 11 | Kyle Lohse | 133 | 2009 | ||
| 12 | Trevor Williams | 131 | 2020 | ||
| 13 | Darryl Kile | 130 | 2001 | ||
| 14 | Brad Radke | 129 | 2000 | ||
| 15 | Zach Miner | 129 | 2007 | ||
| 16 | Javier Vazquez | 128 | 2003 | ||
| 17 | Mat Latos | 128 | 2014 | ||
| 18 | Chan Ho Park | 127 | 2000 | ||
| 19 | Wade Miley | 127 | 2020 | ||
| 20 | Drew Smyly | 126 | 2022 | ||
| 21 | Edwin Jackson | 125 | 2011 | ||
| 22 | Daniel Norris | 125 | 2020 | ||
| 23 | Roy Halladay | 123 | 2003 | ||
| 24 | Jose Urena | 123 | 2018 | ||
| 25 | Pete Harnisch | 121 | 1997 | ||