| Career - Homeruns Allowed | |||
| Rk | Player Name | Totals | |
| 1 | Yu Darvish | 217 | |
| 2 | Brad Radke | 139 | |
| 3 | Pete Harnisch | 134 | |
| 4 | Shohei Ohtani | 125 | |
| 5 | Andy Ashby | 120 | |
| 6 | John Smiley | 116 | |
| 7 | Martin Perez | 108 | |
| 8 | Roy Halladay | 106 | |
| 9 | Daniel Norris | 104 | |
| 10 | Lance Lynn | 102 | |
| 11 | Matt Garza | 90 | |
| 12 | Dustin Hermanson | 89 | |
| 13 | Edwin Jackson | 84 | |
| 14 | Darryl Kile | 81 | |
| 15 | Randy Johnson | 80 | |
| 16 | Joey Hamilton | 78 | |
| 17 | Jake Peavy | 76 | |
| 18 | Michael Wacha | 72 | |
| 19 | Trevor Williams | 69 | |
| 20 | DENNIS MARTINEZ | 68 | |
| 21 | Corey Kluber | 67 | |
| 22 | Jose Urena | 65 | |
| 23 | Garrett Richards | 65 | |
| 24 | Javier Vazquez | 63 | |
| 25 | Drew Smyly | 62 | |
| Single Season - Homeruns Allowed | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | John Smiley | 57 | 1989 | ||
| 2 | Yu Darvish | 52 | 2022 | ||
| 3 | James Shields | 51 | 2019 | ||
| 4 | Lance Lynn | 51 | 2024 | ||
| 5 | Chris Bosio | 49 | 1994 | ||
| 6 | A.J. Griffin | 47 | 2018 | ||
| 7 | Drew Smyly | 45 | 2022 | ||
| 8 | Pete Harnisch | 44 | 1994 | ||
| 9 | Darryl Kile | 42 | 2001 | ||
| 10 | Brad Radke | 42 | 2000 | ||
| 11 | Yu Darvish | 42 | 2020 | ||
| 12 | Daniel Norris | 41 | 2020 | ||
| 13 | Matt Garza | 40 | 2013 | ||
| 14 | Bruce Chen | 39 | 2002 | ||
| 15 | Trevor Williams | 38 | 2020 | ||
| 16 | Tommy Hunter | 37 | 2011 | ||
| 17 | Brandon Finnegan | 37 | 2017 | ||
| 18 | Andy Ashby | 36 | 1995 | ||
| 19 | DENNIS MARTINEZ | 36 | 1991 | ||
| 20 | Chan Ho Park | 35 | 2000 | ||
| 21 | Brad Radke | 35 | 2001 | ||
| 22 | Dustin Hermanson | 35 | 1999 | ||
| 23 | Nathan Eovaldi | 35 | 2023 | ||
| 24 | Jose Urena | 35 | 2018 | ||
| 25 | Yu Darvish | 34 | 2023 | ||