| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Yu Darvish | 220 | |
| 2 | Roy Halladay | 172 | |
| 3 | Pete Harnisch | 168 | |
| 4 | Martin Perez | 163 | |
| 5 | Brad Radke | 149 | |
| 6 | Randy Johnson | 143 | |
| 7 | Shohei Ohtani | 133 | |
| 8 | Andy Ashby | 131 | |
| 9 | Ken Hill | 130 | |
| 10 | DENNIS MARTINEZ | 119 | |
| 11 | Edwin Jackson | 118 | |
| 12 | Mike Morgan | 109 | |
| 13 | Joey Hamilton | 103 | |
| 14 | Dustin Hermanson | 102 | |
| 15 | John Smiley | 98 | |
| 16 | Matt Garza | 98 | |
| 17 | Lance Lynn | 98 | |
| 18 | Corey Kluber | 96 | |
| 19 | Jaime Garcia | 90 | |
| 20 | Jake Peavy | 87 | |
| 21 | Daniel Norris | 81 | |
| 22 | Javier Vazquez | 79 | |
| 23 | Kyle Lohse | 77 | |
| 24 | Lance McCullers | 74 | |
| 25 | Chris Carpenter | 69 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | DENNIS MARTINEZ | 46 | 1991 | ||
| 2 | Chris Bosio | 40 | 1994 | ||
| 3 | Pete Harnisch | 38 | 1994 | ||
| 4 | Randy Johnson | 38 | 1994 | ||
| 5 | Mike Morgan | 38 | 1991 | ||
| 6 | Roy Halladay | 37 | 2003 | ||
| 7 | Ken Hill | 37 | 1994 | ||
| 8 | DENNIS MARTINEZ | 37 | 1993 | ||
| 9 | DENNIS MARTINEZ | 36 | 1992 | ||
| 10 | Mike Morgan | 36 | 1992 | ||
| 11 | Brad Radke | 36 | 2000 | ||
| 12 | John Smiley | 36 | 1995 | ||
| 13 | Roy Halladay | 35 | 2002 | ||
| 14 | Dustin Hermanson | 35 | 2000 | ||
| 15 | Randy Johnson | 35 | 1995 | ||
| 16 | Mike Morgan | 35 | 1993 | ||
| 17 | Brad Radke | 35 | 1999 | ||
| 18 | Brad Radke | 35 | 2001 | ||
| 19 | Kevin Tapani | 35 | 1991 | ||
| 20 | Dustin Hermanson | 35 | 1999 | ||
| 21 | Javier Vazquez | 35 | 2003 | ||
| 22 | Andy Ashby | 34 | 1995 | ||
| 23 | Andy Ashby | 34 | 1996 | ||
| 24 | Chuck Finley | 34 | 1991 | ||
| 25 | Roy Halladay | 34 | 2004 | ||