| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Manny Ramirez | 999 | |
| 2 | Aramis Ramirez | 788 | |
| 3 | Mark Grace | 590 | |
| 4 | Cody Bellinger | 545 | |
| 5 | Miguel Cabrera | 480 | |
| 6 | Angel Pagan | 463 | |
| 7 | Ryne Sandberg | 458 | |
| 8 | Mike Moustakas | 446 | |
| 9 | Joey Gallo | 445 | |
| 10 | Robinson Cano | 442 | |
| 11 | Shohei Ohtani | 434 | |
| 12 | Alfonso Soriano | 412 | |
| 13 | Andruw Jones | 387 | |
| 14 | Mitch Moreland | 387 | |
| 15 | Brian Roberts | 323 | |
| 16 | Walt Weiss | 322 | |
| 17 | Jason Kipnis | 317 | |
| 18 | Jeff Conine | 315 | |
| 19 | Wil Myers | 305 | |
| 20 | Barry Larkin | 304 | |
| 21 | Pat Burrell | 277 | |
| 22 | Bo Bichette | 267 | |
| 23 | Jim Edmonds | 266 | |
| 24 | Travis Fryman | 253 | |
| 25 | Juan Gonzalez | 253 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Ryne Sandberg | 131 | 1994 | ||
| 2 | Orlando Merced | 129 | 1994 | ||
| 3 | Alex Rodriguez | 128 | 2003 | ||
| 4 | Alfonso Soriano | 127 | 2007 | ||
| 5 | Mark Grace | 126 | 1994 | ||
| 6 | Barry Larkin | 126 | 1991 | ||
| 7 | Pete Incaviglia | 125 | 1994 | ||
| 8 | Danny Tartabull | 124 | 1994 | ||
| 9 | Manny Ramirez | 121 | 2003 | ||
| 10 | Alfonso Soriano | 120 | 2003 | ||
| 11 | Manny Ramirez | 117 | 2001 | ||
| 12 | Ryne Sandberg | 117 | 1991 | ||
| 13 | Barry Larkin | 115 | 1992 | ||
| 14 | Jason Bartlett | 114 | 2010 | ||
| 15 | Carlos Beltran | 113 | 2004 | ||
| 16 | Miguel Tejada | 111 | 2006 | ||
| 17 | Brian Roberts | 111 | 2008 | ||
| 18 | Grady Sizemore | 111 | 2008 | ||
| 19 | Manny Ramirez | 110 | 2004 | ||
| 20 | Cody Bellinger | 110 | 2020 | ||
| 21 | Aramis Ramirez | 108 | 2007 | ||
| 22 | Jim Edmonds | 107 | 1997 | ||
| 23 | Manny Ramirez | 107 | 1997 | ||
| 24 | Robinson Cano | 107 | 2011 | ||
| 25 | Asdrubal Cabrera | 104 | 2012 | ||