| Career - Earned Runs | |||
| Rk | Player Name | Totals | |
| 1 | Yu Darvish | 653 | |
| 2 | Martin Perez | 541 | |
| 3 | Roy Halladay | 498 | |
| 4 | Pete Harnisch | 476 | |
| 5 | Brad Radke | 464 | |
| 6 | Shohei Ohtani | 409 | |
| 7 | Andy Ashby | 403 | |
| 8 | Edwin Jackson | 390 | |
| 9 | Lance Lynn | 387 | |
| 10 | Ken Hill | 362 | |
| 11 | Randy Johnson | 347 | |
| 12 | Joey Hamilton | 337 | |
| 13 | Matt Garza | 334 | |
| 14 | Daniel Norris | 317 | |
| 15 | Jaime Garcia | 303 | |
| 16 | Jake Peavy | 303 | |
| 17 | DENNIS MARTINEZ | 302 | |
| 18 | Kyle Lohse | 299 | |
| 19 | Dustin Hermanson | 297 | |
| 20 | Darryl Kile | 270 | |
| 21 | Corey Kluber | 257 | |
| 22 | Javier Vazquez | 256 | |
| 23 | Bud Norris | 253 | |
| 24 | Mike Morgan | 249 | |
| 25 | John Smiley | 244 | |
| Single Season - Earned Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Chris Bosio | 196 | 1994 | ||
| 2 | DENNIS MARTINEZ | 150 | 1991 | ||
| 3 | James Shields | 142 | 2019 | ||
| 4 | Ken Hill | 141 | 1994 | ||
| 5 | Lance Lynn | 141 | 2024 | ||
| 6 | Joey Hamilton | 138 | 1999 | ||
| 7 | Brad Penny | 136 | 2007 | ||
| 8 | Pete Harnisch | 132 | 1994 | ||
| 9 | Matt Garza | 132 | 2011 | ||
| 10 | Chuck Finley | 131 | 1991 | ||
| 11 | Jason Jennings | 131 | 2007 | ||
| 12 | Jason Schmidt | 129 | 1999 | ||
| 13 | Tommy Hunter | 129 | 2011 | ||
| 14 | Yu Darvish | 127 | 2022 | ||
| 15 | Kyle Lohse | 124 | 2009 | ||
| 16 | Brad Radke | 123 | 2001 | ||
| 17 | Drew Smyly | 120 | 2022 | ||
| 18 | Darryl Kile | 119 | 2001 | ||
| 19 | Daniel Norris | 119 | 2020 | ||
| 20 | Chan Ho Park | 118 | 2000 | ||
| 21 | Javier Vazquez | 118 | 2003 | ||
| 22 | Brad Radke | 117 | 2000 | ||
| 23 | Zach Miner | 117 | 2007 | ||
| 24 | Jaime Garcia | 115 | 2012 | ||
| 25 | Jose Urena | 115 | 2018 | ||