| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Jake Peavy | 2069.1 | |
| 2 | Adam Wainwright | 1794.9 | |
| 3 | Tom Glavine | 1344.5 | |
| 4 | Jameson Taillon | 1102.1 | |
| 5 | Tyler Glasnow | 924.5 | |
| 6 | Charles Nagy | 794.1 | |
| 7 | Kevin Brown | 706.0 | |
| 8 | Garrett Richards | 654.1 | |
| 9 | Eric Milton | 561.0 | |
| 10 | Frankie Montas | 531.5 | |
| 11 | Brad Penny | 525.3 | |
| 12 | Jarrod Washburn | 513.3 | |
| 13 | Zack Greinke | 496.2 | |
| 14 | Matt Garza | 489.2 | |
| 15 | Al Leiter | 464.7 | |
| 16 | Kris Benson | 440.7 | |
| 17 | J.A. Happ | 431.4 | |
| 18 | Jaime Garcia | 431.4 | |
| 19 | Michael Pineda | 418.4 | |
| 20 | Jordan Zimmermann | 386.6 | |
| 21 | Jeff Weaver | 357.4 | |
| 22 | Mariano Rivera | 348.4 | |
| 23 | Ryan Yarbrough | 344.2 | |
| 24 | Francisco Rodriguez | 344.1 | |
| 25 | James Shields | 335.1 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Adam Wainwright | 273.1 | 2015 | ||
| 2 | Tom Glavine | 259.2 | 1998 | ||
| 3 | Kevin Brown | 256.3 | 2000 | ||
| 4 | Jake Peavy | 247.0 | 2008 | ||
| 5 | Tom Glavine | 244.0 | 1997 | ||
| 6 | Kevin Brown | 240.7 | 2001 | ||
| 7 | Adam Wainwright | 240.1 | 2010 | ||
| 8 | Tyler Glasnow | 240.1 | 2022 | ||
| 9 | Al Leiter | 235.7 | 1997 | ||
| 10 | Matt Garza | 230.0 | 2014 | ||
| 11 | Garrett Richards | 230.0 | 2015 | ||
| 12 | Adam Wainwright | 229.1 | 2011 | ||
| 13 | Adam Wainwright | 228.1 | 2014 | ||
| 14 | Jake Peavy | 227.0 | 2006 | ||
| 15 | Adam Wainwright | 225.0 | 2009 | ||
| 16 | Dan Haren | 224.1 | 2007 | ||
| 17 | Charles Nagy | 223.7 | 1997 | ||
| 18 | Frankie Montas | 223.1 | 2022 | ||
| 19 | Kris Benson | 222.0 | 2001 | ||
| 20 | Brad Penny | 222.0 | 2005 | ||
| 21 | Matt Garza | 220.2 | 2015 | ||
| 22 | Charles Nagy | 219.1 | 1998 | ||
| 23 | Kris Benson | 218.7 | 2000 | ||
| 24 | Jameson Taillon | 218.0 | 2019 | ||
| 25 | Tom Glavine | 217.0 | 1999 | ||