| Career - Strikeouts | |||
| Rk | Player Name | Totals | |
| 1 | Albert Pujols | 1271 | |
| 2 | Trevor Story | 1054 | |
| 3 | Ronald Acuna | 979 | |
| 4 | Christian Yelich | 957 | |
| 5 | Brandon Nimmo | 833 | |
| 6 | Brandon Belt | 819 | |
| 7 | Jose Canseco | 665 | |
| 8 | Paul Goldschmidt | 568 | |
| 9 | Derek Jeter | 535 | |
| 10 | Kolten Wong | 526 | |
| 11 | Ken Caminiti | 485 | |
| 12 | Robinson Cano | 460 | |
| 13 | Brian McRae | 437 | |
| 14 | Tyler Flowers | 431 | |
| 15 | John Mabry | 405 | |
| 16 | Chase Headley | 391 | |
| 17 | Colby Rasmus | 369 | |
| 18 | Kelly Shoppach | 368 | |
| 19 | Javy Lopez | 356 | |
| 20 | B.J. Upton | 320 | |
| 21 | Carlos Garcia | 306 | |
| 22 | Stephen Drew | 306 | |
| 23 | Juan Uribe | 283 | |
| 24 | Tim Salmon | 276 | |
| 25 | Jim Thome | 265 | |
| Single Season - Strikeouts | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Ronald Acuna | 233 | 2020 | ||
| 2 | Kelly Shoppach | 227 | 2009 | ||
| 3 | Ronald Acuna | 227 | 2021 | ||
| 4 | Jim Thome | 213 | 2012 | ||
| 5 | Matt Tuiasosopo | 211 | 2014 | ||
| 6 | Colby Rasmus | 203 | 2011 | ||
| 7 | Trevor Story | 199 | 2020 | ||
| 8 | Ronald Acuna | 193 | 2019 | ||
| 9 | Brandon Belt | 193 | 2022 | ||
| 10 | Craig A. Wilson | 187 | 2002 | ||
| 11 | John Mabry | 186 | 2005 | ||
| 12 | Rickie Weeks | 185 | 2010 | ||
| 13 | Christian Yelich | 185 | 2020 | ||
| 14 | Trevor Story | 183 | 2019 | ||
| 15 | Paul Goldschmidt | 181 | 2023 | ||
| 16 | Chase Headley | 178 | 2013 | ||
| 17 | Paul Goldschmidt | 178 | 2024 | ||
| 18 | Al Martin | 175 | 1994 | ||
| 19 | B.J. Upton | 175 | 2008 | ||
| 20 | Eric Haase | 175 | 2023 | ||
| 21 | Jose Siri | 173 | 2024 | ||
| 22 | Nelson Cruz | 170 | 2009 | ||
| 23 | Trevor Story | 168 | 2017 | ||
| 24 | Tyler Flowers | 168 | 2020 | ||
| 25 | Derek Jeter | 164 | 1999 | ||