| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Albert Pujols | 1720 | |
| 2 | Ronald Acuna | 616 | |
| 3 | Christian Yelich | 590 | |
| 4 | Brandon Nimmo | 512 | |
| 5 | Brandon Belt | 473 | |
| 6 | Trevor Story | 463 | |
| 7 | Robinson Cano | 414 | |
| 8 | Jose Canseco | 413 | |
| 9 | Derek Jeter | 384 | |
| 10 | Brian McRae | 351 | |
| 11 | Ken Caminiti | 329 | |
| 12 | Kolten Wong | 324 | |
| 13 | Paul Goldschmidt | 309 | |
| 14 | Todd Helton | 297 | |
| 15 | Will Clark | 266 | |
| 16 | John Mabry | 256 | |
| 17 | Brian Giles | 253 | |
| 18 | Carlos Garcia | 225 | |
| 19 | Nolan Arenado | 223 | |
| 20 | Charlie Blackmon | 212 | |
| 21 | B.J. Upton | 204 | |
| 22 | Juan Uribe | 196 | |
| 23 | Wil Cordero | 193 | |
| 24 | Colby Rasmus | 191 | |
| 25 | Chase Headley | 191 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Christian Yelich | 143 | 2020 | ||
| 2 | Albert Pujols | 140 | 2010 | ||
| 3 | Ronald Acuna | 140 | 2024 | ||
| 4 | Albert Pujols | 137 | 2009 | ||
| 5 | Albert Pujols | 136 | 2006 | ||
| 6 | Albert Pujols | 132 | 2005 | ||
| 7 | Shawn Green | 126 | 2003 | ||
| 8 | Derek Jeter | 126 | 2000 | ||
| 9 | Randy Winn | 125 | 2003 | ||
| 10 | Bob Abreu | 124 | 2000 | ||
| 11 | Nelson Cruz | 123 | 2009 | ||
| 12 | Ronald Acuna | 122 | 2020 | ||
| 13 | Frank Thomas | 121 | 2001 | ||
| 14 | Brandon Belt | 120 | 2021 | ||
| 15 | Eric Hosmer | 117 | 2014 | ||
| 16 | J.D. Drew | 116 | 2002 | ||
| 17 | Albert Pujols | 116 | 2003 | ||
| 18 | Albert Pujols | 116 | 2004 | ||
| 19 | Brian Giles | 116 | 2006 | ||
| 20 | Dustin Pedroia | 115 | 2012 | ||
| 21 | Robinson Cano | 115 | 2014 | ||
| 22 | Todd Helton | 113 | 2006 | ||
| 23 | Charlie Blackmon | 113 | 2017 | ||
| 24 | Ronald Acuna | 113 | 2021 | ||
| 25 | Al Martin | 112 | 1994 | ||