| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Jake Peavy | 338 | |
| 2 | Adam Wainwright | 247 | |
| 3 | Tom Glavine | 216 | |
| 4 | Jameson Taillon | 201 | |
| 5 | Tyler Glasnow | 145 | |
| 6 | Charles Nagy | 129 | |
| 7 | Kevin Brown | 104 | |
| 8 | Eric Milton | 96 | |
| 9 | Garrett Richards | 92 | |
| 10 | Brad Penny | 89 | |
| 11 | Zack Greinke | 88 | |
| 12 | Jarrod Washburn | 87 | |
| 13 | Al Leiter | 80 | |
| 14 | Frankie Montas | 76 | |
| 15 | Michael Pineda | 75 | |
| 16 | Jaime Garcia | 74 | |
| 17 | Matt Garza | 73 | |
| 18 | Kris Benson | 69 | |
| 19 | Jordan Zimmermann | 66 | |
| 20 | J.A. Happ | 59 | |
| 21 | Randy Johnson | 58 | |
| 22 | Nathan Eovaldi | 58 | |
| 23 | Joe Musgrove | 55 | |
| 24 | Ryan Yarbrough | 54 | |
| 25 | James Shields | 53 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Frankie Montas | 37 | 2022 | ||
| 2 | Kris Benson | 36 | 2001 | ||
| 3 | Brad Penny | 36 | 2005 | ||
| 4 | Tom Glavine | 36 | 1999 | ||
| 5 | Dan Haren | 36 | 2007 | ||
| 6 | Adam Wainwright | 36 | 2009 | ||
| 7 | Tyler Glasnow | 36 | 2021 | ||
| 8 | Tyler Glasnow | 36 | 2022 | ||
| 9 | Jameson Taillon | 36 | 2023 | ||
| 10 | Charles Nagy | 35 | 1998 | ||
| 11 | Kevin Brown | 35 | 2000 | ||
| 12 | Kevin Brown | 35 | 2001 | ||
| 13 | Tom Glavine | 35 | 1998 | ||
| 14 | Eric Milton | 35 | 2000 | ||
| 15 | Jake Peavy | 35 | 2004 | ||
| 16 | Jake Peavy | 35 | 2005 | ||
| 17 | Jake Peavy | 35 | 2006 | ||
| 18 | Jake Peavy | 35 | 2008 | ||
| 19 | Brian Anderson | 35 | 1999 | ||
| 20 | Paul Maholm | 35 | 2009 | ||
| 21 | Jake Peavy | 35 | 2010 | ||
| 22 | Adam Wainwright | 35 | 2010 | ||
| 23 | Adam Wainwright | 35 | 2013 | ||
| 24 | Matt Garza | 35 | 2014 | ||
| 25 | Adam Wainwright | 35 | 2014 | ||