| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Cole Hamels | 732 | |
| 2 | Brandon Webb | 539 | |
| 3 | Bronson Arroyo | 526 | |
| 4 | Denny Neagle | 415 | |
| 5 | Marcus Stroman | 414 | |
| 6 | John Maine | 365 | |
| 7 | Clayton Richard | 354 | |
| 8 | Joe Saunders | 339 | |
| 9 | Dan Straily | 318 | |
| 10 | Brett Anderson | 308 | |
| 11 | Kevin Brown | 307 | |
| 12 | John Thomson | 297 | |
| 13 | Terry Adams | 279 | |
| 14 | Alex Fernandez | 262 | |
| 15 | Doug Davis | 262 | |
| 16 | Bud Norris | 252 | |
| 17 | Johnny Cueto | 246 | |
| 18 | Jon Garland | 242 | |
| 19 | Steven Matz | 237 | |
| 20 | A.J. Burnett | 235 | |
| 21 | Bruce Chen | 230 | |
| 22 | Curt Schilling | 227 | |
| 23 | Mark Redman | 224 | |
| 24 | Eric Lauer | 222 | |
| 25 | Kwang Hyun Kim | 215 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Tom Glavine | 179 | 2000 | ||
| 2 | Steve Woodard | 153 | 2000 | ||
| 3 | Shane Reynolds | 147 | 2002 | ||
| 4 | Brandon Webb | 140 | 2006 | ||
| 5 | Jason Bere | 138 | 2002 | ||
| 6 | Steve Sparks | 135 | 2002 | ||
| 7 | Alex Fernandez | 134 | 1998 | ||
| 8 | Bronson Arroyo | 132 | 2006 | ||
| 9 | Jon Garland | 131 | 2003 | ||
| 10 | Ervin Santana | 131 | 2011 | ||
| 11 | R.A. Dickey | 131 | 2013 | ||
| 12 | Kwang Hyun Kim | 131 | 2022 | ||
| 13 | Clayton Richard | 129 | 2011 | ||
| 14 | Alex Fernandez | 128 | 1997 | ||
| 15 | Ramon Ortiz | 128 | 2002 | ||
| 16 | Bud Norris | 128 | 2014 | ||
| 17 | Terry Adams | 127 | 2003 | ||
| 18 | Sidney Ponson | 127 | 2001 | ||
| 19 | Bruce Chen | 127 | 2012 | ||
| 20 | Marcus Stroman | 127 | 2017 | ||
| 21 | Eric Lauer | 127 | 2020 | ||
| 22 | John Thomson | 126 | 2004 | ||
| 23 | Terry Adams | 125 | 2002 | ||
| 24 | Adam Wainwright | 124 | 2020 | ||
| 25 | John Thomson | 123 | 2005 | ||