| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Cole Hamels | 233 | |
| 2 | Roger Clemens | 194 | |
| 3 | Brandon Webb | 171 | |
| 4 | Kevin Brown | 163 | |
| 5 | Denny Neagle | 154 | |
| 6 | DOUG DRABEK | 151 | |
| 7 | Bronson Arroyo | 137 | |
| 8 | Alex Fernandez | 131 | |
| 9 | Marcus Stroman | 131 | |
| 10 | John Maine | 103 | |
| 11 | Joe Saunders | 102 | |
| 12 | Dan Straily | 96 | |
| 13 | Chris Bosio | 94 | |
| 14 | Brett Anderson | 91 | |
| 15 | NOLAN RYAN | 89 | |
| 16 | Ken Hill | 82 | |
| 17 | Erik Hanson | 81 | |
| 18 | John Thomson | 81 | |
| 19 | Clayton Richard | 74 | |
| 20 | Terry Adams | 66 | |
| 21 | Wilson Alvarez | 66 | |
| 22 | A.J. Burnett | 66 | |
| 23 | Jeff Niemann | 65 | |
| 24 | Johnny Cueto | 65 | |
| 25 | Eric Lauer | 65 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Roger Clemens | 46 | 1991 | ||
| 2 | DOUG DRABEK | 46 | 1991 | ||
| 3 | Roger Clemens | 42 | 1990 | ||
| 4 | Don Robinson | 42 | 1990 | ||
| 5 | Erik Hanson | 41 | 1991 | ||
| 6 | Erik Hanson | 40 | 1990 | ||
| 7 | Tom Glavine | 37 | 2000 | ||
| 8 | Mike Morgan | 37 | 1994 | ||
| 9 | Roger Clemens | 36 | 1994 | ||
| 10 | Rheal Cormier | 36 | 1994 | ||
| 11 | DOUG DRABEK | 36 | 1993 | ||
| 12 | Alex Fernandez | 36 | 1998 | ||
| 13 | Bronson Arroyo | 36 | 2006 | ||
| 14 | Brandon Webb | 36 | 2006 | ||
| 15 | Bronson Arroyo | 36 | 2007 | ||
| 16 | Curt Schilling | 36 | 2007 | ||
| 17 | Joe Saunders | 36 | 2009 | ||
| 18 | Brandon Webb | 36 | 2009 | ||
| 19 | Joe Saunders | 36 | 2010 | ||
| 20 | Denny Neagle | 35 | 1998 | ||
| 21 | Roger Clemens | 35 | 1992 | ||
| 22 | Roger Clemens | 35 | 1993 | ||
| 23 | DOUG DRABEK | 35 | 1992 | ||
| 24 | Kevin Brown | 35 | 1998 | ||
| 25 | Danny Jackson | 35 | 1990 | ||