| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Ken Griffey Jr | 938 | |
| 2 | Juan Gonzalez | 525 | |
| 3 | David Peralta | 447 | |
| 4 | David Segui | 439 | |
| 5 | Bob Abreu | 401 | |
| 6 | Ivan Rodriguez | 358 | |
| 7 | Torii Hunter | 352 | |
| 8 | Dave Magadan | 340 | |
| 9 | Melky Cabrera | 339 | |
| 10 | Bobby Abreu | 335 | |
| 11 | Jay Payton | 320 | |
| 12 | Ben Revere | 317 | |
| 13 | Bill Spiers | 295 | |
| 14 | Carlos Gomez | 283 | |
| 15 | Shannon Stewart | 278 | |
| 16 | Placido Polanco | 278 | |
| 17 | Jorge Polanco | 278 | |
| 18 | Gregg Jefferies | 275 | |
| 19 | Howard Kendrick | 274 | |
| 20 | Hanley Ramirez | 271 | |
| 21 | Chili Davis | 265 | |
| 22 | Dee Gordon | 264 | |
| 23 | Andruw Jones | 252 | |
| 24 | Ryan Howard | 251 | |
| 25 | Nelson Cruz | 248 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Ken Griffey Jr | 146 | 1994 | ||
| 2 | Ken Griffey Jr. | 140 | 1999 | ||
| 3 | Gregg Jefferies | 134 | 1991 | ||
| 4 | Jose Offerman | 134 | 1994 | ||
| 5 | Juan Gonzalez | 131 | 1994 | ||
| 6 | Bob Abreu | 125 | 2003 | ||
| 7 | Paul Sorrento | 121 | 1994 | ||
| 8 | Ken Griffey Jr | 120 | 1997 | ||
| 9 | Ruben Sierra | 119 | 1991 | ||
| 10 | Torii Hunter | 118 | 2010 | ||
| 11 | Ryan Howard | 117 | 2007 | ||
| 12 | Bob Abreu | 116 | 2002 | ||
| 13 | Hanley Ramirez | 115 | 2007 | ||
| 14 | Ken Griffey | 113 | 2000 | ||
| 15 | David Segui | 113 | 2002 | ||
| 16 | Bobby Abreu | 113 | 2010 | ||
| 17 | Dave Magadan | 111 | 1991 | ||
| 18 | Nick Johnson | 110 | 2007 | ||
| 19 | Rafael Palmeiro | 109 | 1999 | ||
| 20 | Kelly Gruber | 107 | 1991 | ||
| 21 | Darryl Hamilton | 107 | 1994 | ||
| 22 | Juan Gonzalez | 106 | 1997 | ||
| 23 | Delino DeShields | 105 | 1999 | ||
| 24 | David Segui | 105 | 1994 | ||
| 25 | Ken Griffey Jr | 104 | 1991 | ||