| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Jon Lester | 1165.8 | |
| 2 | Freddy Garcia | 1021.5 | |
| 3 | Derek Lowe | 997.9 | |
| 4 | Bartolo Colon | 894.7 | |
| 5 | Josh Johnson | 824.3 | |
| 6 | J.A. Happ | 698.2 | |
| 7 | Steven Matz | 551.6 | |
| 8 | Chad Billingsley | 526.2 | |
| 9 | Carlos Zambrano | 509.7 | |
| 10 | Jason Marquis | 474.0 | |
| 11 | Andrew Heaney | 465.4 | |
| 12 | Michael Fulmer | 451.2 | |
| 13 | Aaron Harang | 415.4 | |
| 14 | Scott Kazmir | 402.2 | |
| 15 | Brad Ziegler | 385.3 | |
| 16 | Jarrod Parker | 379.3 | |
| 17 | Zach Duke | 371.1 | |
| 18 | Chad Gaudin | 365.4 | |
| 19 | Randy Wells | 348.0 | |
| 20 | David Robertson | 344.6 | |
| 21 | Robinson Tejeda | 340.2 | |
| 22 | Ryan Franklin | 336.0 | |
| 23 | Zack Wheeler | 330.0 | |
| 24 | Brandon Morrow | 329.2 | |
| 25 | Eddie Guardado | 299.3 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Michael Fulmer | 252.2 | 2018 | ||
| 2 | Carlos Zambrano | 235.7 | 2004 | ||
| 3 | Ryan Franklin | 232.0 | 2004 | ||
| 4 | Bartolo Colon | 231.1 | 2017 | ||
| 5 | Aaron Harang | 226.2 | 2008 | ||
| 6 | Freddy Garcia | 223.0 | 2005 | ||
| 7 | Freddy Garcia | 221.0 | 2007 | ||
| 8 | Mike Minor | 221.0 | 2020 | ||
| 9 | Derek Lowe | 220.2 | 2009 | ||
| 10 | Randy Wells | 220.0 | 2010 | ||
| 11 | Josh Johnson | 219.1 | 2010 | ||
| 12 | David Bush | 213.3 | 2005 | ||
| 13 | Freddy Garcia | 210.2 | 2006 | ||
| 14 | Jon Lester | 210.2 | 2015 | ||
| 15 | Josh Johnson | 209.0 | 2011 | ||
| 16 | J.A. Happ | 208.0 | 2019 | ||
| 17 | Jason Marquis | 206.3 | 2005 | ||
| 18 | Jon Lester | 206.2 | 2011 | ||
| 19 | Jason Marquis | 205.0 | 2006 | ||
| 20 | Jarrod Parker | 202.2 | 2013 | ||
| 21 | Mike Pelfrey | 201.0 | 2011 | ||
| 22 | Andy Ashby | 199.7 | 2003 | ||
| 23 | Kevin Millwood | 199.2 | 2010 | ||
| 24 | Michael Fulmer | 199.0 | 2017 | ||
| 25 | Freddy Garcia | 197.3 | 2004 | ||