| Career - Strikeouts | |||
| Rk | Player Name | Totals | |
| 1 | Carlos Beltran | 1088 | |
| 2 | Yasiel Puig | 796 | |
| 3 | Ichiro Suzuki | 740 | |
| 4 | Yadier Molina | 726 | |
| 5 | Justin Turner | 629 | |
| 6 | Jeff Kent | 602 | |
| 7 | Kyle Seager | 558 | |
| 8 | Jose Abreu | 502 | |
| 9 | Shin-Soo Choo | 477 | |
| 10 | Josh Phelps | 475 | |
| 11 | Willy Adames | 472 | |
| 12 | Dmitri Young | 419 | |
| 13 | Mark Canha | 406 | |
| 14 | Javy Lopez | 393 | |
| 15 | Jimmy Rollins | 385 | |
| 16 | Dustin Ackley | 381 | |
| 17 | Mike Cameron | 339 | |
| 18 | John Jaso | 313 | |
| 19 | Starlin Castro | 312 | |
| 20 | Jason Giambi | 289 | |
| 21 | Colby Rasmus | 277 | |
| 22 | Troy Glaus | 274 | |
| 23 | Dustin Pedroia | 271 | |
| 24 | Nick Ahmed | 270 | |
| 25 | Alejandro De Aza | 264 | |
| Single Season - Strikeouts | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Jack Cust | 254 | 2009 | ||
| 2 | Colby Rasmus | 239 | 2015 | ||
| 3 | Josh Phelps | 233 | 2003 | ||
| 4 | Willy Adames | 218 | 2021 | ||
| 5 | Chris Colabello | 203 | 2016 | ||
| 6 | Mike Cameron | 198 | 2003 | ||
| 7 | Jose Abreu | 187 | 2021 | ||
| 8 | Mark Canha | 187 | 2021 | ||
| 9 | Josh Phelps | 183 | 2004 | ||
| 10 | Mike Tauchman | 178 | 2020 | ||
| 11 | Jose Abreu | 174 | 2020 | ||
| 12 | Corey Patterson | 173 | 2005 | ||
| 13 | Troy Glaus | 168 | 2008 | ||
| 14 | Shin-Soo Choo | 167 | 2014 | ||
| 15 | Mark Canha | 163 | 2020 | ||
| 16 | Yasiel Puig | 157 | 2014 | ||
| 17 | Kole Calhoun | 156 | 2021 | ||
| 18 | Jayson Werth | 154 | 2010 | ||
| 19 | Carlos Pena | 154 | 2012 | ||
| 20 | Dmitri Young | 153 | 2004 | ||
| 21 | Rickie Weeks | 153 | 2015 | ||
| 22 | Alejandro De Aza | 152 | 2013 | ||
| 23 | Asdrubal Cabrera | 152 | 2020 | ||
| 24 | Franmil Reyes | 151 | 2019 | ||
| 25 | Andrew Knapp | 149 | 2021 | ||