| Career - Earned Runs | |||
| Rk | Player Name | Totals | |
| 1 | Jon Lester | 615 | |
| 2 | Freddy Garcia | 575 | |
| 3 | Derek Lowe | 518 | |
| 4 | Bartolo Colon | 457 | |
| 5 | Josh Johnson | 372 | |
| 6 | J.A. Happ | 368 | |
| 7 | Chad Billingsley | 322 | |
| 8 | Jason Marquis | 292 | |
| 9 | Steven Matz | 288 | |
| 10 | Andrew Heaney | 250 | |
| 11 | Carlos Zambrano | 246 | |
| 12 | Chad Gaudin | 235 | |
| 13 | Jarrod Parker | 200 | |
| 14 | Scott Kazmir | 198 | |
| 15 | Aaron Harang | 195 | |
| 16 | Zack Wheeler | 192 | |
| 17 | Ryan Franklin | 186 | |
| 18 | John Lannan | 182 | |
| 19 | Robinson Tejeda | 179 | |
| 20 | Derek Holland | 168 | |
| 21 | Chris Reitsma | 166 | |
| 22 | Zach Duke | 160 | |
| 23 | Yovani Gallardo | 159 | |
| 24 | Brandon Morrow | 156 | |
| 25 | Brad Ziegler | 156 | |
| Single Season - Earned Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Chris Reitsma | 150 | 2003 | ||
| 2 | Jason Marquis | 138 | 2005 | ||
| 3 | Chad Billingsley | 126 | 2009 | ||
| 4 | Andy Ashby | 125 | 2003 | ||
| 5 | Freddy Garcia | 124 | 2004 | ||
| 6 | Ryan Franklin | 119 | 2004 | ||
| 7 | Freddy Garcia | 119 | 2005 | ||
| 8 | Jason Marquis | 119 | 2006 | ||
| 9 | Chad Gaudin | 119 | 2008 | ||
| 10 | Derek Holland | 118 | 2012 | ||
| 11 | Freddy Garcia | 117 | 2006 | ||
| 12 | Freddy Garcia | 116 | 2007 | ||
| 13 | John Lannan | 116 | 2010 | ||
| 14 | Yovani Gallardo | 114 | 2016 | ||
| 15 | Jon Lester | 112 | 2015 | ||
| 16 | Aaron Harang | 110 | 2007 | ||
| 17 | David Bush | 109 | 2005 | ||
| 18 | Josh Johnson | 109 | 2011 | ||
| 19 | Carlos Zambrano | 106 | 2004 | ||
| 20 | Randy Wolf | 106 | 2009 | ||
| 21 | Derek Lowe | 105 | 2008 | ||
| 22 | Jon Lester | 105 | 2014 | ||
| 23 | Jordan Lyles | 105 | 2020 | ||
| 24 | Derek Lowe | 104 | 2010 | ||
| 25 | Edinson Volquez | 104 | 2013 | ||