| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Sonny Gray | 1831.9 | |
| 2 | Andy Benes | 1723.0 | |
| 3 | Johan Santana | 1399.3 | |
| 4 | Ramon Martinez | 1166.2 | |
| 5 | Pedro Martinez | 1118.8 | |
| 6 | Clay Buchholz | 1013.7 | |
| 7 | Josh Beckett | 984.9 | |
| 8 | Jimmy Key | 974.7 | |
| 9 | Rich Harden | 913.3 | |
| 10 | Ben Sheets | 898.7 | |
| 11 | Kyle Hendricks | 864.5 | |
| 12 | Wade Miller | 806.3 | |
| 13 | Zach Eflin | 692.6 | |
| 14 | Dylan Bundy | 662.4 | |
| 15 | Chad Green | 533.4 | |
| 16 | Arthur Rhodes | 514.6 | |
| 17 | Stephen Strasburg | 503.5 | |
| 18 | Collin McHugh | 501.2 | |
| 19 | Kevin Tapani | 496.3 | |
| 20 | Pat Hentgen | 459.7 | |
| 21 | Justin Thompson | 439.6 | |
| 22 | Hideo Nomo | 420.3 | |
| 23 | Edinson Volquez | 410.6 | |
| 24 | Felix Hernandez | 398.2 | |
| 25 | Juan Guzman | 366.3 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Tim Belcher | 294.7 | 1993 | ||
| 2 | Andy Benes | 286.0 | 1993 | ||
| 3 | Pedro J. Martinez | 270.2 | 1998 | ||
| 4 | Pedro Martinez | 268.0 | 2001 | ||
| 5 | Jimmy Key | 263.3 | 1993 | ||
| 6 | Steve Ontiveros | 261.7 | 1995 | ||
| 7 | Pat Hentgen | 260.3 | 1997 | ||
| 8 | Kevin Tapani | 256.0 | 1992 | ||
| 9 | Andy Benes | 255.3 | 1992 | ||
| 10 | Pedro Martinez | 253.7 | 2000 | ||
| 11 | Jimmy Key | 252.7 | 1995 | ||
| 12 | Hideo Nomo | 245.0 | 1997 | ||
| 13 | Kevin Tapani | 240.3 | 1993 | ||
| 14 | Pedro Martinez | 236.1 | 1999 | ||
| 15 | Ramon Martinez | 234.0 | 1992 | ||
| 16 | Josh Beckett | 233.2 | 2008 | ||
| 17 | Jimmy Key | 232.0 | 1994 | ||
| 18 | Corey Kluber | 231.2 | 2018 | ||
| 19 | Johan Santana | 229.1 | 2006 | ||
| 20 | Andy Benes | 227.7 | 1995 | ||
| 21 | John Burkett | 226.7 | 1994 | ||
| 22 | Jimmy Key | 226.7 | 1992 | ||
| 23 | Kyle Hendricks | 226.0 | 2021 | ||
| 24 | Johan Santana | 223.3 | 2005 | ||
| 25 | Pedro Martinez | 221.3 | 2002 | ||