| Career - Homeruns Allowed | |||
| Rk | Player Name | Totals | |
| 1 | Sonny Gray | 220 | |
| 2 | Johan Santana | 197 | |
| 3 | Josh Beckett | 156 | |
| 4 | Andy Benes | 156 | |
| 5 | Kyle Hendricks | 130 | |
| 6 | Ben Sheets | 126 | |
| 7 | Clay Buchholz | 121 | |
| 8 | Pedro Martinez | 118 | |
| 9 | Wade Miller | 114 | |
| 10 | Ramon Martinez | 109 | |
| 11 | Zach Eflin | 107 | |
| 12 | Rich Harden | 105 | |
| 13 | Dylan Bundy | 96 | |
| 14 | Jimmy Key | 80 | |
| 15 | Chris Paddack | 80 | |
| 16 | Chad Green | 79 | |
| 17 | Collin McHugh | 68 | |
| 18 | Stephen Strasburg | 64 | |
| 19 | Rick Helling | 52 | |
| 20 | Arthur Rhodes | 52 | |
| 21 | Jose Lima | 51 | |
| 22 | Edward Cabrera | 51 | |
| 23 | Pat Hentgen | 49 | |
| 24 | Edinson Volquez | 48 | |
| 25 | Vladmir Nunez | 47 | |
| Single Season - Homeruns Allowed | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Wade Miller | 43 | 2002 | ||
| 2 | Josh Beckett | 43 | 2007 | ||
| 3 | Chris Paddack | 43 | 2021 | ||
| 4 | Grayson Rodriguez | 43 | 2024 | ||
| 5 | Pedro Martinez | 42 | 2001 | ||
| 6 | Tim Stauffer | 40 | 2012 | ||
| 7 | Curt Schilling | 38 | 2000 | ||
| 8 | Clay Buchholz | 38 | 2012 | ||
| 9 | A.J. Griffin | 38 | 2013 | ||
| 10 | Josh Beckett | 37 | 2008 | ||
| 11 | Chris Paddack | 37 | 2020 | ||
| 12 | Johan Santana | 36 | 2004 | ||
| 13 | Johan Santana | 35 | 2005 | ||
| 14 | Ben Sheets | 35 | 2006 | ||
| 15 | Kyle Kendrick | 34 | 2012 | ||
| 16 | Taijuan Walker | 34 | 2017 | ||
| 17 | Zach Eflin | 34 | 2019 | ||
| 18 | Chris Young | 33 | 2010 | ||
| 19 | Lance Lynn | 33 | 2023 | ||
| 20 | Reese Olson | 33 | 2024 | ||
| 21 | Hideo Nomo | 32 | 1997 | ||
| 22 | Ben Sheets | 32 | 2005 | ||
| 23 | Pedro Martinez | 32 | 1999 | ||
| 24 | Anibal Sanchez | 32 | 2010 | ||
| 25 | Chris Ellis | 32 | 2022 | ||