| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Sonny Gray | 300 | |
| 2 | Andy Benes | 265 | |
| 3 | Johan Santana | 225 | |
| 4 | Ramon Martinez | 208 | |
| 5 | Pedro Martinez | 162 | |
| 6 | Rich Harden | 161 | |
| 7 | Josh Beckett | 156 | |
| 8 | Clay Buchholz | 151 | |
| 9 | Jimmy Key | 149 | |
| 10 | Ben Sheets | 140 | |
| 11 | Kyle Hendricks | 122 | |
| 12 | Wade Miller | 109 | |
| 13 | Zach Eflin | 103 | |
| 14 | Dylan Bundy | 96 | |
| 15 | Stephen Strasburg | 89 | |
| 16 | Collin McHugh | 81 | |
| 17 | Edinson Volquez | 71 | |
| 18 | Justin Thompson | 70 | |
| 19 | Kevin Tapani | 67 | |
| 20 | Hideo Nomo | 65 | |
| 21 | Pat Hentgen | 62 | |
| 22 | Felix Hernandez | 62 | |
| 23 | Edward Cabrera | 61 | |
| 24 | Juan Guzman | 60 | |
| 25 | Tim Stauffer | 53 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Jimmy Key | 43 | 1995 | ||
| 2 | Ramon Martinez | 40 | 1995 | ||
| 3 | Steve Ontiveros | 40 | 1995 | ||
| 4 | Andy Benes | 39 | 1995 | ||
| 5 | Johan Santana | 37 | 2003 | ||
| 6 | Tim Belcher | 36 | 1993 | ||
| 7 | Jimmy Key | 36 | 1993 | ||
| 8 | Pedro Martinez | 36 | 1999 | ||
| 9 | Kevin Tapani | 36 | 1992 | ||
| 10 | Rich Harden | 36 | 2006 | ||
| 11 | Johan Santana | 36 | 2006 | ||
| 12 | Andy Benes | 35 | 1992 | ||
| 13 | Andy Benes | 35 | 1993 | ||
| 14 | Jimmy Key | 35 | 1992 | ||
| 15 | Jimmy Key | 35 | 1994 | ||
| 16 | Pedro Martinez | 35 | 2001 | ||
| 17 | Justin Thompson | 35 | 1999 | ||
| 18 | Ben Sheets | 35 | 2006 | ||
| 19 | Pedro J. Martinez | 34 | 1998 | ||
| 20 | John Burkett | 34 | 1994 | ||
| 21 | Kelvim Escobar | 34 | 2002 | ||
| 22 | Pedro Martinez | 34 | 2002 | ||
| 23 | Ramon Martinez | 34 | 1994 | ||
| 24 | Ramon Martinez | 34 | 1997 | ||
| 25 | Hideo Nomo | 34 | 1997 | ||