| Career - Games | |||
| Rk | Player Name | Totals | |
| 1 | Drew Storen | 249 | |
| 2 | Tony Watson | 239 | |
| 3 | Liam Hendriks | 203 | |
| 4 | Daniel Hudson | 193 | |
| 5 | Andrew Chafin | 183 | |
| 6 | James Paxton | 179 | |
| 7 | Luis Cessa | 170 | |
| 8 | Jeremy Jeffress | 157 | |
| 9 | Masahiro Tanaka | 146 | |
| 10 | Jordan Hicks | 146 | |
| 11 | Fernando Rodney | 144 | |
| 12 | Bryan Shaw | 142 | |
| 13 | Sean Doolittle | 128 | |
| 14 | Paul Fry | 117 | |
| 15 | Archie Bradley | 106 | |
| 16 | R.A. Dickey | 102 | |
| 17 | Carson Smith | 102 | |
| 18 | CC Sabathia | 96 | |
| 19 | John Means | 96 | |
| 20 | Zach McAllister | 93 | |
| 21 | Louis Coleman | 92 | |
| 22 | Charlie Furbush | 89 | |
| 23 | Lou Trivino | 89 | |
| 24 | John Axford | 88 | |
| 25 | Hyun-Jin Ryu | 85 | |
| Single Season - Games | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Andrew Chafin | 107 | 2016 | ||
| 2 | Luis Cessa | 103 | 2021 | ||
| 3 | Jeremy Jeffress | 102 | 2016 | ||
| 4 | Carson Smith | 102 | 2016 | ||
| 5 | Drew Storen | 100 | 2016 | ||
| 6 | Zach McAllister | 93 | 2018 | ||
| 7 | Louis Coleman | 92 | 2019 | ||
| 8 | Fernando Rodney | 90 | 2015 | ||
| 9 | Charlie Furbush | 89 | 2015 | ||
| 10 | Lou Trivino | 89 | 2019 | ||
| 11 | Bryan Shaw | 86 | 2018 | ||
| 12 | Daniel Winkler | 84 | 2019 | ||
| 13 | Tony Watson | 83 | 2019 | ||
| 14 | Drew Storen | 81 | 2015 | ||
| 15 | Chad Qualls | 80 | 2015 | ||
| 16 | Tony Watson | 80 | 2018 | ||
| 17 | Jordan Hicks | 80 | 2019 | ||
| 18 | A.J. Minter | 80 | 2019 | ||
| 19 | Cory Gearrin | 77 | 2018 | ||
| 20 | Andrew Chafin | 76 | 2018 | ||
| 21 | Tony Watson | 76 | 2021 | ||
| 22 | Daniel Hudson | 75 | 2021 | ||
| 23 | Sean Doolittle | 74 | 2014 | ||
| 24 | Emilio Pagan | 73 | 2020 | ||
| 25 | Seung Hwan Oh | 71 | 2018 | ||