| Career - Earned Runs | |||
| Rk | Player Name | Totals | |
| 1 | James Paxton | 449 | |
| 2 | Masahiro Tanaka | 437 | |
| 3 | R.A. Dickey | 339 | |
| 4 | CC Sabathia | 295 | |
| 5 | John Means | 291 | |
| 6 | Tyler Anderson | 234 | |
| 7 | Jeremy Hellickson | 218 | |
| 8 | Hyun-Jin Ryu | 206 | |
| 9 | Felix Hernandez | 195 | |
| 10 | Alex Cobb | 171 | |
| 11 | Hyun Jin Ryu | 158 | |
| 12 | C.C. Sabathia | 142 | |
| 13 | Vincent Velasquez | 130 | |
| 14 | Tony Watson | 126 | |
| 15 | John Danks | 124 | |
| 16 | Reynaldo Lopez | 124 | |
| 17 | Hector Santiago | 117 | |
| 18 | Daniel Hudson | 112 | |
| 19 | Wily Peralta | 111 | |
| 20 | Andrew Cashner | 108 | |
| 21 | Ricky Nolasco | 106 | |
| 22 | Luis Cessa | 102 | |
| 23 | Wade Miley | 99 | |
| 24 | Nathan Karns | 98 | |
| 25 | Chris Stratton | 97 | |
| Single Season - Earned Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | C.C. Sabathia | 142 | 2015 | ||
| 2 | Jeremy Hellickson | 136 | 2014 | ||
| 3 | Masahiro Tanaka | 128 | 2018 | ||
| 4 | CC Sabathia | 125 | 2018 | ||
| 5 | John Danks | 124 | 2014 | ||
| 6 | Reynaldo Lopez | 124 | 2019 | ||
| 7 | R.A. Dickey | 122 | 2014 | ||
| 8 | CC Sabathia | 121 | 2017 | ||
| 9 | Hector Santiago | 117 | 2014 | ||
| 10 | R.A. Dickey | 113 | 2015 | ||
| 11 | John Means | 113 | 2021 | ||
| 12 | Wily Peralta | 111 | 2022 | ||
| 13 | Ricky Nolasco | 106 | 2017 | ||
| 14 | R.A. Dickey | 104 | 2016 | ||
| 15 | John Means | 104 | 2020 | ||
| 16 | Andrew Cashner | 102 | 2020 | ||
| 17 | Tyler Anderson | 100 | 2022 | ||
| 18 | Wade Miley | 99 | 2016 | ||
| 19 | Felix Hernandez | 99 | 2018 | ||
| 20 | Hyun-Jin Ryu | 99 | 2020 | ||
| 21 | Nathan Karns | 98 | 2016 | ||
| 22 | Chris Stratton | 97 | 2018 | ||
| 23 | Erick Fedde | 97 | 2021 | ||
| 24 | Tyler Anderson | 95 | 2021 | ||
| 25 | Erasmo Ramirez | 94 | 2014 | ||