| Career - Strikeouts | |||
| Rk | Player Name | Totals | |
| 1 | Alex Gordon | 853 | |
| 2 | Matt Kemp | 767 | |
| 3 | Chris Carter | 745 | |
| 4 | Paul DeJong | 720 | |
| 5 | Francisco Lindor | 516 | |
| 6 | Pete Alonso | 498 | |
| 7 | Asdrubal Cabrera | 485 | |
| 8 | Trey Mancini | 399 | |
| 9 | Chris Owings | 361 | |
| 10 | Michael Bourn | 293 | |
| 11 | Martin Maldonado | 278 | |
| 12 | Randal Grichuk | 261 | |
| 13 | Robinson Chirinos | 244 | |
| 14 | J.D. Martinez | 242 | |
| 15 | Ben Paulsen | 232 | |
| 16 | Jake Cronenworth | 230 | |
| 17 | Alex Avila | 223 | |
| 18 | Max Kepler | 222 | |
| 19 | Corey Dickerson | 215 | |
| 20 | Whit Merrifield | 200 | |
| 21 | Victor Robles | 200 | |
| 22 | Tom Murphy | 191 | |
| 23 | Josh Reddick | 187 | |
| 24 | Harrison Bader | 187 | |
| 25 | Alberto Callaspo | 185 | |
| Single Season - Strikeouts | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Chris Carter | 241 | 2017 | ||
| 2 | Chris Carter | 228 | 2014 | ||
| 3 | Paul DeJong | 211 | 2018 | ||
| 4 | Chris Carter | 209 | 2015 | ||
| 5 | Matt Kemp | 204 | 2016 | ||
| 6 | Alex Gordon | 203 | 2017 | ||
| 7 | Pete Alonso | 203 | 2020 | ||
| 8 | Randal Grichuk | 199 | 2018 | ||
| 9 | Tom Murphy | 191 | 2020 | ||
| 10 | Harrison Bader | 187 | 2019 | ||
| 11 | Matt Kemp | 185 | 2015 | ||
| 12 | Robinson Chirinos | 185 | 2016 | ||
| 13 | Martin Maldonado | 184 | 2021 | ||
| 14 | Paul DeJong | 181 | 2020 | ||
| 15 | Alex Avila | 175 | 2015 | ||
| 16 | Matt Kemp | 174 | 2017 | ||
| 17 | Alex Gordon | 171 | 2015 | ||
| 18 | Pete Alonso | 167 | 2021 | ||
| 19 | J.D. Martinez | 166 | 2018 | ||
| 20 | Paul DeJong | 165 | 2021 | ||
| 21 | Paul DeJong | 163 | 2019 | ||
| 22 | Zack Collins | 163 | 2022 | ||
| 23 | Lucas Duda | 162 | 2018 | ||
| 24 | Michael Morse | 157 | 2015 | ||
| 25 | Michael Bourn | 154 | 2014 | ||