| Career - Saves | |||
| Rk | Player Name | Totals | |
| 1 | Bobby Jenks | 105 | |
| 2 | Troy Percival | 87 | |
| 3 | Jonathan Papelbon | 72 | |
| 4 | Greg Holland | 54 | |
| 5 | Mark Wohlers | 52 | |
| 6 | Francisco Cordero | 52 | |
| 7 | Tyler Rogers | 37 | |
| 8 | Mike Jackson | 36 | |
| 9 | Junichi Tazawa | 32 | |
| 10 | Bobby Ayala | 31 | |
| 11 | Tim Worrell | 30 | |
| 12 | Garrett Whitlock | 29 | |
| 13 | Scott Radinsky | 24 | |
| 14 | Steve Cishek | 23 | |
| 15 | Octavio Dotel | 22 | |
| 16 | Doug Henry | 19 | |
| 17 | John Rocker | 19 | |
| 18 | Jeurys Familia | 19 | |
| 19 | Carlos Martinez | 19 | |
| 20 | Tom Henke | 17 | |
| 21 | Donn Pall | 17 | |
| 22 | Mike Timlin | 17 | |
| 23 | Adbert Alzolay | 17 | |
| 24 | Scott Bankhead | 16 | |
| 25 | Robb Nen | 16 | |
| Single Season - Saves | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Bobby Jenks | 40 | 2008 | ||
| 2 | Jonathan Papelbon | 35 | 2016 | ||
| 3 | Tyler Rogers | 35 | 2023 | ||
| 4 | Troy Percival | 34 | 2002 | ||
| 5 | Bobby Ayala | 29 | 1995 | ||
| 6 | Mike Jackson | 29 | 1992 | ||
| 7 | Junichi Tazawa | 29 | 2013 | ||
| 8 | Garrett Whitlock | 29 | 2022 | ||
| 9 | Francisco Cordero | 28 | 2012 | ||
| 10 | Greg Holland | 27 | 2021 | ||
| 11 | Mark Wohlers | 26 | 1997 | ||
| 12 | Greg Holland | 26 | 2018 | ||
| 13 | Bobby Jenks | 25 | 2007 | ||
| 14 | Steve Cishek | 23 | 2017 | ||
| 15 | Tim Worrell | 21 | 2004 | ||
| 16 | Bobby Jenks | 21 | 2009 | ||
| 17 | Francisco Cordero | 20 | 2011 | ||
| 18 | Jonathan Papelbon | 20 | 2015 | ||
| 19 | Troy Percival | 19 | 2001 | ||
| 20 | Bobby Jenks | 19 | 2010 | ||
| 21 | Jeurys Familia | 19 | 2019 | ||
| 22 | Carlos Martinez | 19 | 2020 | ||
| 23 | Troy Percival | 18 | 2005 | ||
| 24 | Tom Henke | 17 | 1994 | ||
| 25 | Mike Timlin | 17 | 2006 | ||