| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Wilson Alvarez | 261 | |
| 2 | Jon Lieber | 250 | |
| 3 | Frank Viola | 198 | |
| 4 | Clayton Kershaw | 178 | |
| 5 | Todd Stottlemyre | 169 | |
| 6 | Lucas Giolito | 146 | |
| 7 | German Marquez | 141 | |
| 8 | Jaime Navarro | 137 | |
| 9 | James Shields | 117 | |
| 10 | Jason Hammel | 116 | |
| 11 | Barry Zito | 110 | |
| 12 | Greg Maddux | 103 | |
| 13 | Rick Porcello | 103 | |
| 14 | DENNIS MARTINEZ | 100 | |
| 15 | Logan Webb | 93 | |
| 16 | Tyler Mahle | 92 | |
| 17 | Ricky Bones | 91 | |
| 18 | Kent Bottenfield | 88 | |
| 19 | Javier Vazquez | 88 | |
| 20 | Nathan Eovaldi | 85 | |
| 21 | Jose Quintana | 74 | |
| 22 | Daisuke Matsuzaka | 72 | |
| 23 | Drew Smyly | 70 | |
| 24 | Freddy Garcia | 69 | |
| 25 | Jason Schmidt | 69 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Frank Viola | 47 | 1990 | ||
| 2 | Jim Deshaies | 46 | 1991 | ||
| 3 | Frank Viola | 46 | 1991 | ||
| 4 | Randy Johnson | 41 | 1990 | ||
| 5 | Jim Neidlinger | 41 | 1991 | ||
| 6 | Scott Bankhead | 40 | 1990 | ||
| 7 | Juan Guzman | 37 | 2000 | ||
| 8 | Greg Hibbard | 37 | 1990 | ||
| 9 | Jon Lieber | 37 | 2000 | ||
| 10 | Greg Maddux | 36 | 2004 | ||
| 11 | Todd Stottlemyre | 36 | 1999 | ||
| 12 | Charles Nagy | 36 | 1993 | ||
| 13 | Jaime Navarro | 36 | 1993 | ||
| 14 | Jon Lieber | 36 | 1999 | ||
| 15 | Frank Viola | 36 | 1992 | ||
| 16 | Freddy Garcia | 35 | 2002 | ||
| 17 | Wilson Alvarez | 35 | 1998 | ||
| 18 | Jon Lieber | 35 | 2001 | ||
| 19 | Jaime Navarro | 35 | 1992 | ||
| 20 | Frank Viola | 35 | 1994 | ||
| 21 | Wilson Alvarez | 34 | 1994 | ||
| 22 | Jon Lieber | 34 | 1998 | ||
| 23 | Pedro Astacio | 34 | 1998 | ||
| 24 | Cory Lidle | 34 | 2003 | ||
| 25 | Jon Lieber | 34 | 2002 | ||