| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Curt Schilling | 1226.4 | |
| 2 | Carlos Carrasco | 970.1 | |
| 3 | Trevor Bauer | 635.5 | |
| 4 | Aaron Sele | 618.0 | |
| 5 | Mike Hampton | 606.5 | |
| 6 | Dave Burba | 601.0 | |
| 7 | Rick Porcello | 594.3 | |
| 8 | Danny Salazar | 575.4 | |
| 9 | Bartolo Colon | 525.7 | |
| 10 | Ryan Dempster | 500.1 | |
| 11 | Justin Masterson | 479.3 | |
| 12 | Cory Lidle | 469.0 | |
| 13 | Kevin Millwood | 454.6 | |
| 14 | Mike Clevinger | 418.5 | |
| 15 | Phil Hughes | 413.2 | |
| 16 | Wade Miley | 401.2 | |
| 17 | DOUG DRABEK | 378.0 | |
| 18 | Aaron Civale | 355.3 | |
| 19 | Jake Westbrook | 353.3 | |
| 20 | Mark Buehrle | 339.2 | |
| 21 | Cliff Lee | 323.2 | |
| 22 | Jeremy Bonderman | 319.1 | |
| 23 | John Lackey | 313.9 | |
| 24 | Kent Mercker | 307.0 | |
| 25 | Fausto Carmona | 301.2 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Curt Schilling | 266.7 | 1997 | ||
| 2 | DOUG DRABEK | 253.0 | 1995 | ||
| 3 | Curt Schilling | 249.0 | 1999 | ||
| 4 | Kevin Millwood | 239.3 | 2000 | ||
| 5 | Curt Schilling | 238.0 | 1998 | ||
| 6 | Curt Schilling | 227.7 | 1994 | ||
| 7 | Russ Ortiz | 226.0 | 2002 | ||
| 8 | Justin Masterson | 226.0 | 2012 | ||
| 9 | Dave Burba | 225.0 | 2000 | ||
| 10 | Cory Lidle | 221.3 | 2002 | ||
| 11 | Bartolo Colon | 219.3 | 2002 | ||
| 12 | Phil Hughes | 216.2 | 2015 | ||
| 13 | Aaron Sele | 213.0 | 2000 | ||
| 14 | Steve Trachsel | 211.0 | 1997 | ||
| 15 | Cliff Lee | 210.1 | 2007 | ||
| 16 | Tim Belcher | 209.0 | 1994 | ||
| 17 | Charles Nagy | 205.7 | 2000 | ||
| 18 | Rick Porcello | 203.1 | 2012 | ||
| 19 | Greg Hibbard | 202.3 | 1994 | ||
| 20 | Ricky Nolasco | 202.2 | 2013 | ||
| 21 | Brian Duensing | 202.0 | 2011 | ||
| 22 | Dave Burba | 201.0 | 1999 | ||
| 23 | Wade Miley | 200.2 | 2022 | ||
| 24 | Jordan Zimmermann | 199.0 | 2016 | ||
| 25 | Trevor Bauer | 198.1 | 2020 | ||