| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Curt Schilling | 184 | |
| 2 | Carlos Carrasco | 162 | |
| 3 | Trevor Bauer | 110 | |
| 4 | Aaron Sele | 107 | |
| 5 | Dave Burba | 104 | |
| 6 | Danny Salazar | 104 | |
| 7 | Rick Porcello | 92 | |
| 8 | Bartolo Colon | 81 | |
| 9 | Ryan Dempster | 81 | |
| 10 | Mike Clevinger | 78 | |
| 11 | Kevin Millwood | 70 | |
| 12 | Wade Miley | 68 | |
| 13 | DOUG DRABEK | 65 | |
| 14 | Aaron Civale | 64 | |
| 15 | Kent Mercker | 63 | |
| 16 | Phil Hughes | 61 | |
| 17 | Mike Hampton | 59 | |
| 18 | Cliff Lee | 58 | |
| 19 | Mark Buehrle | 54 | |
| 20 | Jake Westbrook | 53 | |
| 21 | Cory Lidle | 52 | |
| 22 | John Lackey | 51 | |
| 23 | Ramon Ortiz | 49 | |
| 24 | Shelby Miller | 49 | |
| 25 | Jeremy Bonderman | 48 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Dave Burba | 36 | 2000 | ||
| 2 | Curt Schilling | 36 | 1999 | ||
| 3 | Bartolo Colon | 35 | 2002 | ||
| 4 | Cory Lidle | 35 | 2002 | ||
| 5 | Aaron Sele | 35 | 1999 | ||
| 6 | Russ Ortiz | 35 | 2002 | ||
| 7 | Aaron Sele | 35 | 2000 | ||
| 8 | Curt Schilling | 35 | 1998 | ||
| 9 | DOUG DRABEK | 34 | 1995 | ||
| 10 | Greg Hibbard | 34 | 1994 | ||
| 11 | Kevin Millwood | 34 | 2000 | ||
| 12 | Curt Schilling | 34 | 1994 | ||
| 13 | Dave Burba | 34 | 1999 | ||
| 14 | Tim Belcher | 33 | 1994 | ||
| 15 | Charlie Leibrandt | 33 | 1994 | ||
| 16 | Kent Mercker | 33 | 1995 | ||
| 17 | Charles Nagy | 33 | 2000 | ||
| 18 | Curt Schilling | 33 | 1997 | ||
| 19 | Kevin Tapani | 33 | 1994 | ||
| 20 | Cliff Lee | 33 | 2007 | ||
| 21 | Justin Masterson | 33 | 2012 | ||
| 22 | Trevor Bauer | 33 | 2017 | ||
| 23 | Trevor Bauer | 33 | 2018 | ||
| 24 | Trevor Bauer | 33 | 2020 | ||
| 25 | Tarik Skubal | 33 | 2021 | ||