| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Roy Oswalt | 2315.7 | |
| 2 | A.J. Burnett | 1966.2 | |
| 3 | Kevin Appier | 1858.6 | |
| 4 | Roger Clemens | 1731.2 | |
| 5 | Tim Lincecum | 1353.8 | |
| 6 | Blake Snell | 1282.6 | |
| 7 | Zane Smith | 1061.4 | |
| 8 | Jose Quintana | 959.4 | |
| 9 | Randy Wolf | 951.2 | |
| 10 | Lance Lynn | 893.3 | |
| 11 | Josh Collmenter | 720.5 | |
| 12 | Jose Fernandez | 690.4 | |
| 13 | Miguel Gonzalez | 596.6 | |
| 14 | Logan Gilbert | 584.6 | |
| 15 | Dave Stieb | 583.7 | |
| 16 | Tim Wakefield | 580.1 | |
| 17 | Jose Mesa | 538.8 | |
| 18 | Kevin Brown | 537.4 | |
| 19 | Tyler Alexander | 530.3 | |
| 20 | Paul Abbott | 505.4 | |
| 21 | Kevin Tapani | 491.0 | |
| 22 | Joaquin Benoit | 446.4 | |
| 23 | Tom Browning | 436.0 | |
| 24 | Scott Downs | 433.3 | |
| 25 | Daniel Hudson | 433.2 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Zane Smith | 351.7 | 1991 | ||
| 2 | Mike Scott | 329.7 | 1990 | ||
| 3 | Kevin Brown | 288.7 | 1993 | ||
| 4 | Rick Sutcliffe | 283.7 | 1990 | ||
| 5 | Dave Stieb | 283.0 | 1991 | ||
| 6 | Kevin Appier | 273.0 | 1993 | ||
| 7 | Kevin Appier | 269.7 | 1991 | ||
| 8 | Zane Smith | 265.7 | 1992 | ||
| 9 | Kevin Appier | 265.0 | 1998 | ||
| 10 | Kevin Appier | 260.3 | 1994 | ||
| 11 | Dave Fleming | 253.0 | 1993 | ||
| 12 | Kevin Brown | 248.7 | 1994 | ||
| 13 | Tom Browning | 247.0 | 1990 | ||
| 14 | Paul Abbott | 245.7 | 2000 | ||
| 15 | Kevin Tapani | 240.0 | 1997 | ||
| 16 | Roy Oswalt | 237.2 | 2006 | ||
| 17 | Roger Clemens | 235.2 | 2006 | ||
| 18 | Zach Plesac | 232.0 | 2021 | ||
| 19 | Miguel Gonzalez | 230.2 | 2013 | ||
| 20 | Daniel Hudson | 228.2 | 2011 | ||
| 21 | Greg W. Harris | 228.0 | 1992 | ||
| 22 | A.J. Burnett | 226.7 | 2003 | ||
| 23 | Mike Moore | 224.3 | 1994 | ||
| 24 | Jose Fernandez | 224.1 | 2014 | ||
| 25 | Cody Anderson | 224.1 | 2016 | ||