| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Roy Oswalt | 361 | |
| 2 | A.J. Burnett | 307 | |
| 3 | Roger Clemens | 287 | |
| 4 | Kevin Appier | 273 | |
| 5 | Blake Snell | 253 | |
| 6 | Tim Lincecum | 214 | |
| 7 | Randy Wolf | 165 | |
| 8 | Jose Quintana | 156 | |
| 9 | Lance Lynn | 150 | |
| 10 | Zane Smith | 141 | |
| 11 | Jose Fernandez | 106 | |
| 12 | Logan Gilbert | 99 | |
| 13 | Dave Stieb | 98 | |
| 14 | Josh Collmenter | 96 | |
| 15 | Tim Wakefield | 92 | |
| 16 | Miguel Gonzalez | 91 | |
| 17 | Kevin Tapani | 81 | |
| 18 | Tom Browning | 76 | |
| 19 | Paul Abbott | 74 | |
| 20 | Kevin Brown | 70 | |
| 21 | Dave Stewart | 67 | |
| 22 | Alex Cobb | 65 | |
| 23 | Tom Gorzelanny | 64 | |
| 24 | Daniel Hudson | 64 | |
| 25 | Jeremy Hellickson | 63 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Zane Smith | 48 | 1991 | ||
| 2 | Kevin Appier | 46 | 1991 | ||
| 3 | Mike Scott | 43 | 1990 | ||
| 4 | Dave Stieb | 43 | 1991 | ||
| 5 | Rick Sutcliffe | 40 | 1990 | ||
| 6 | Tom Browning | 38 | 1990 | ||
| 7 | Kevin Appier | 36 | 1993 | ||
| 8 | Kevin Brown | 36 | 1993 | ||
| 9 | Tom Browning | 36 | 1991 | ||
| 10 | Roger Clemens | 36 | 2004 | ||
| 11 | Zane Smith | 36 | 1992 | ||
| 12 | Randy Wolf | 36 | 2004 | ||
| 13 | A.J. Burnett | 36 | 2006 | ||
| 14 | Roy Oswalt | 36 | 2006 | ||
| 15 | Logan Gilbert | 36 | 2023 | ||
| 16 | Blake Snell | 36 | 2023 | ||
| 17 | Spencer Strider | 36 | 2023 | ||
| 18 | Hideo Nomo | 35 | 1998 | ||
| 19 | Tim Belcher | 35 | 1990 | ||
| 20 | Mike Morgan | 35 | 1998 | ||
| 21 | Roger Clemens | 35 | 2002 | ||
| 22 | Kevin Appier | 35 | 1998 | ||
| 23 | Paul Abbott | 34 | 2001 | ||
| 24 | Kevin Appier | 34 | 1992 | ||
| 25 | Kevin Appier | 34 | 1994 | ||