| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Chris Sale | 2188.2 | |
| 2 | Jamie Moyer | 1808.8 | |
| 3 | David Cone | 1504.5 | |
| 4 | Kevin Gausman | 1442.2 | |
| 5 | Roy Halladay | 1426.5 | |
| 6 | Andy Pettitte | 995.8 | |
| 7 | Kenley Jansen | 868.8 | |
| 8 | Jeff Fassero | 814.7 | |
| 9 | Julio Urias | 785.4 | |
| 10 | Mark Buehrle | 775.8 | |
| 11 | Jon Gray | 735.1 | |
| 12 | Greg Swindell | 667.7 | |
| 13 | Ted Lilly | 649.1 | |
| 14 | Derek Lowe | 621.2 | |
| 15 | Anibal Sanchez | 612.6 | |
| 16 | Gil Heredia | 578.7 | |
| 17 | Ian Kennedy | 564.4 | |
| 18 | Edwin Diaz | 524.4 | |
| 19 | Pete Harnisch | 500.8 | |
| 20 | C.C. Sabathia | 454.0 | |
| 21 | Jonathan Papelbon | 445.5 | |
| 22 | Robbie Ray | 441.1 | |
| 23 | Jose DeJesus | 440.7 | |
| 24 | Chris Haney | 407.4 | |
| 25 | Bob Tewksbury | 398.6 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | ED WHITSON | 339.0 | 1990 | ||
| 2 | John Tudor | 317.0 | 1991 | ||
| 3 | Greg Maddux | 302.0 | 1990 | ||
| 4 | Greg Swindell | 301.0 | 1990 | ||
| 5 | Chris Sale | 282.2 | 2014 | ||
| 6 | Roy Halladay | 274.0 | 2009 | ||
| 7 | David Cone | 271.7 | 1994 | ||
| 8 | Oil Can Boyd | 260.3 | 1991 | ||
| 9 | Roy Halladay | 260.2 | 2011 | ||
| 10 | Derek Lowe | 257.7 | 2003 | ||
| 11 | Chris Sale | 253.1 | 2015 | ||
| 12 | Jamie Moyer | 252.2 | 1999 | ||
| 13 | Chris Sale | 252.1 | 2018 | ||
| 14 | David Cone | 252.0 | 1992 | ||
| 15 | Jamie Moyer | 249.3 | 2003 | ||
| 16 | Jamie Moyer | 249.0 | 1998 | ||
| 17 | Jose Guzman | 248.7 | 1992 | ||
| 18 | Roy Halladay | 248.0 | 2008 | ||
| 19 | Jeff Fassero | 247.7 | 1997 | ||
| 20 | David Cone | 244.3 | 1995 | ||
| 21 | Jamie Moyer | 244.3 | 2000 | ||
| 22 | Javier Vazquez | 244.2 | 2010 | ||
| 23 | Chris Sale | 244.2 | 2016 | ||
| 24 | Bob Tewksbury | 242.3 | 1992 | ||
| 25 | Justin Masterson | 242.1 | 2014 | ||