| Career - Games Started | |||
| Rk | Player Name | Totals | |
| 1 | Dallas Keuchel | 215 | |
| 2 | Brandon Woodruff | 157 | |
| 3 | Hideo Nomo | 156 | |
| 4 | Ismael Valdes | 154 | |
| 5 | SID FERNANDEZ | 137 | |
| 6 | Cal Eldred | 130 | |
| 7 | Shane Reynolds | 126 | |
| 8 | Tim Wakefield | 126 | |
| 9 | Ervin Santana | 117 | |
| 10 | Terry Mulholland | 102 | |
| 11 | Chase Anderson | 102 | |
| 12 | Gil Meche | 100 | |
| 13 | Kyle Freeland | 99 | |
| 14 | Darryl Kile | 97 | |
| 15 | Erik Hanson | 97 | |
| 16 | Jon Lester | 96 | |
| 17 | Chuck Finley | 94 | |
| 18 | Eric King | 84 | |
| 19 | Bobby Witt | 79 | |
| 20 | Robert Person | 77 | |
| 21 | Andy Ashby | 71 | |
| 22 | Triston McKenzie | 67 | |
| 23 | Jae Seo | 63 | |
| 24 | Antonio Senzatela | 62 | |
| 25 | Johnny Cueto | 60 | |
| Single Season - Games Started | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Bobby Witt | 46 | 1991 | ||
| 2 | Eric King | 43 | 1991 | ||
| 3 | John Smoltz | 42 | 1990 | ||
| 4 | Eric King | 41 | 1990 | ||
| 5 | John Dopson | 39 | 1990 | ||
| 6 | SID FERNANDEZ | 38 | 1991 | ||
| 7 | Rodrigo Lopez | 36 | 2003 | ||
| 8 | Terry Mulholland | 36 | 1994 | ||
| 9 | Hideo Nomo | 36 | 2003 | ||
| 10 | Hideo Nomo | 36 | 2004 | ||
| 11 | Curt Schilling | 36 | 1993 | ||
| 12 | Jose Contreras | 36 | 2006 | ||
| 13 | Andy Ashby | 36 | 1999 | ||
| 14 | Scott Feldman | 36 | 2010 | ||
| 15 | Jeremy Guthrie | 36 | 2011 | ||
| 16 | Andy Ashby | 35 | 2000 | ||
| 17 | Darryl Kile | 35 | 1998 | ||
| 18 | Cal Eldred | 35 | 1993 | ||
| 19 | Cal Eldred | 35 | 1994 | ||
| 20 | SID FERNANDEZ | 35 | 1993 | ||
| 21 | Terry Mulholland | 35 | 1992 | ||
| 22 | Jae Seo | 35 | 2006 | ||
| 23 | Gil Meche | 35 | 2008 | ||
| 24 | Wade Davis | 35 | 2010 | ||
| 25 | Dallas Keuchel | 35 | 2016 | ||