| Career - Games | |||
| Rk | Player Name | Totals | |
| 1 | Brad Brach | 273 | |
| 2 | Scott Sullivan | 259 | |
| 3 | Dallas Keuchel | 249 | |
| 4 | Brandon Woodruff | 238 | |
| 5 | Ismael Valdes | 228 | |
| 6 | Pedro Strop | 199 | |
| 7 | Caleb Thielbar | 199 | |
| 8 | Clay Holmes | 194 | |
| 9 | Joakim Soria | 188 | |
| 10 | SID FERNANDEZ | 166 | |
| 11 | Hideo Nomo | 165 | |
| 12 | Gregg Olson | 161 | |
| 13 | Casey Janssen | 160 | |
| 14 | J.B. Wendelken | 155 | |
| 15 | B.J. Ryan | 153 | |
| 16 | David Hernandez | 145 | |
| 17 | Tanner Rainey | 143 | |
| 18 | Chris Ray | 135 | |
| 19 | Mel Rojas | 132 | |
| 20 | Cal Eldred | 130 | |
| 21 | Damaso Marte | 130 | |
| 22 | Tim Wakefield | 127 | |
| 23 | Terry Mulholland | 126 | |
| 24 | Shane Reynolds | 126 | |
| 25 | Eric O'Flaherty | 125 | |
| Single Season - Games | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Mel Rojas | 91 | 1995 | ||
| 2 | George Kontos | 91 | 2015 | ||
| 3 | Junior Guerra | 91 | 2020 | ||
| 4 | J.B. Wendelken | 88 | 2020 | ||
| 5 | Jose DeLeon | 87 | 1995 | ||
| 6 | Anthony Swarzak | 84 | 2014 | ||
| 7 | Jimmy Cordero | 83 | 2020 | ||
| 8 | Jason Kershner | 82 | 2004 | ||
| 9 | Gregg Olson | 82 | 1991 | ||
| 10 | Scott Sullivan | 81 | 2002 | ||
| 11 | Brad Brach | 81 | 2018 | ||
| 12 | David Hernandez | 81 | 2018 | ||
| 13 | Brandon Woodruff | 81 | 2019 | ||
| 14 | Matt Bowman | 81 | 2020 | ||
| 15 | Mark Corey | 80 | 2004 | ||
| 16 | Jay Witasick | 80 | 2003 | ||
| 17 | Fabio Castro | 80 | 2007 | ||
| 18 | Gregg Olson | 79 | 1990 | ||
| 19 | Cesar Valdez | 79 | 2021 | ||
| 20 | Steve Cishek | 76 | 2012 | ||
| 21 | Spencer Patton | 76 | 2022 | ||
| 22 | Jose Ruiz | 76 | 2022 | ||
| 23 | Derek Lowe | 75 | 2000 | ||
| 24 | Tanner Rainey | 75 | 2021 | ||
| 25 | Sean Manaea | 75 | 2024 | ||