| Career - Games | |||
| Rk | Player Name | Totals | |
| 1 | Joe Nathan | 401 | |
| 2 | Mark Melancon | 278 | |
| 3 | Tony Watson | 263 | |
| 4 | Aaron Sanchez | 229 | |
| 5 | Juan Rincon | 224 | |
| 6 | Zack Wheeler | 198 | |
| 7 | Johnny Cueto | 197 | |
| 8 | Carl Edwards | 182 | |
| 9 | Will Harris | 174 | |
| 10 | Justin Wilson | 168 | |
| 11 | Noah Syndergaard | 152 | |
| 12 | Wandy Rodriguez | 150 | |
| 13 | Jason Adam | 131 | |
| 14 | Vin Mazzaro | 129 | |
| 15 | Troy Patton | 126 | |
| 16 | Camilo Doval | 120 | |
| 17 | Zack Britton | 120 | |
| 18 | A.J. Puk | 111 | |
| 19 | Mike Montgomery | 110 | |
| 20 | Ken Giles | 110 | |
| 21 | Francisco Liriano | 107 | |
| 22 | Russ Ortiz | 101 | |
| 23 | Shane McClanahan | 99 | |
| 24 | Dominic Leone | 85 | |
| 25 | Wilton Lopez | 84 | |
| Single Season - Games | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Vin Mazzaro | 129 | 2014 | ||
| 2 | Dominic Leone | 85 | 2018 | ||
| 3 | Jakob Junis | 82 | 2024 | ||
| 4 | Paul Quantrill | 78 | 2003 | ||
| 5 | Aaron Sanchez | 78 | 2015 | ||
| 6 | Danny Barnes | 77 | 2018 | ||
| 7 | Will Harris | 77 | 2018 | ||
| 8 | Tony Watson | 76 | 2017 | ||
| 9 | Mark Melancon | 74 | 2016 | ||
| 10 | Kyle Funkhouser | 74 | 2022 | ||
| 11 | Tony Watson | 73 | 2016 | ||
| 12 | David Hale | 72 | 2020 | ||
| 13 | Heath Bell | 70 | 2008 | ||
| 14 | Hansel Robles | 70 | 2016 | ||
| 15 | Ryan Dull | 70 | 2017 | ||
| 16 | Alexi Ogando | 69 | 2011 | ||
| 17 | Carl Edwards | 69 | 2018 | ||
| 18 | Zack Britton | 69 | 2021 | ||
| 19 | Mark Melancon | 68 | 2017 | ||
| 20 | Zach Britton | 68 | 2019 | ||
| 21 | Hirokazu Sawamura | 68 | 2022 | ||
| 22 | Jason Adam | 68 | 2024 | ||
| 23 | Brad Lidge | 67 | 2011 | ||
| 24 | Aaron Sanchez | 66 | 2016 | ||
| 25 | Shawn Tolleson | 66 | 2016 | ||