| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Mookie Betts | 966 | |
| 2 | Craig Biggio | 869 | |
| 3 | Jason Giambi | 802 | |
| 4 | Josh Donaldson | 660 | |
| 5 | Edwin Encarnacion | 659 | |
| 6 | TONY GWYNN | 617 | |
| 7 | KEVIN MITCHELL | 521 | |
| 8 | Carlos Guillen | 503 | |
| 9 | Dante Bichette | 451 | |
| 10 | Travis Hafner | 445 | |
| 11 | Don Mattingly | 415 | |
| 12 | Matt Holliday | 324 | |
| 13 | Tino Martinez | 315 | |
| 14 | Steve Sax | 310 | |
| 15 | Eugenio Suarez | 300 | |
| 16 | Ian Happ | 293 | |
| 17 | Dexter Fowler | 254 | |
| 18 | Alan Trammell | 244 | |
| 19 | Corey Koskie | 229 | |
| 20 | Mike Piazza | 224 | |
| 21 | Mike Napoli | 220 | |
| 22 | Seth Smith | 217 | |
| 23 | Mike Greenwell | 212 | |
| 24 | Hanley Ramirez | 197 | |
| 25 | Darin Erstad | 193 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Alan Trammell | 162 | 1994 | ||
| 2 | Jason Giambi | 161 | 2002 | ||
| 3 | KEVIN MITCHELL | 153 | 1989 | ||
| 4 | Craig Biggio | 141 | 1999 | ||
| 5 | KEVIN MITCHELL | 138 | 1990 | ||
| 6 | TONY GWYNN | 137 | 1994 | ||
| 7 | Mookie Betts | 133 | 2020 | ||
| 8 | KEVIN MITCHELL | 128 | 1991 | ||
| 9 | Dante Bichette | 126 | 1994 | ||
| 10 | Edwin Encarnacion | 124 | 2013 | ||
| 11 | Don Mattingly | 121 | 1994 | ||
| 12 | Mike Macfarlane | 120 | 1994 | ||
| 13 | Steve Sax | 119 | 1990 | ||
| 14 | Miguel Tejada | 119 | 2003 | ||
| 15 | Craig Biggio | 118 | 1998 | ||
| 16 | Steve Sax | 118 | 1991 | ||
| 17 | Mookie Betts | 117 | 2019 | ||
| 18 | Jeff Kent | 115 | 2003 | ||
| 19 | Craig Biggio | 114 | 1995 | ||
| 20 | Roger Cedeno | 113 | 2002 | ||
| 21 | Jason Giambi | 113 | 2001 | ||
| 22 | Josh Donaldson | 113 | 2018 | ||
| 23 | TONY GWYNN | 112 | 1995 | ||
| 24 | Carlos Guillen | 111 | 2005 | ||
| 25 | Mookie Betts | 111 | 2023 | ||