| Career - Saves | |||
| Rk | Player Name | Totals | |
| 1 | Mariano Rivera | 525 | |
| 2 | Troy Percival | 339 | |
| 3 | Trevor Hoffman | 338 | |
| 4 | Billy Wagner | 289 | |
| 5 | Jonathan Papelbon | 274 | |
| 6 | Kenley Jansen | 254 | |
| 7 | Francisco Rodriguez | 248 | |
| 8 | Joe Nathan | 245 | |
| 9 | Huston Street | 241 | |
| 10 | Craig Kimbrel | 240 | |
| 11 | Jason Isringhausen | 229 | |
| 12 | Robb Nen | 219 | |
| 13 | Joakim Soria | 192 | |
| 14 | Jose Valverde | 180 | |
| 15 | Armando Benitez | 167 | |
| 16 | Tom Gordon | 166 | |
| 17 | J.J. Putz | 162 | |
| 18 | Jeff Montgomery | 159 | |
| 19 | Wade Davis | 159 | |
| 20 | Mike Jackson | 155 | |
| 21 | Raisel Iglesias | 144 | |
| 22 | Keith Foulke | 140 | |
| 23 | John Wetteland | 138 | |
| 24 | Rod Beck | 136 | |
| 25 | Ugueth Urbina | 134 | |
| Single Season - Saves | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | DUANE WARD | 47 | 1992 | ||
| 2 | Scott Stewart | 46 | 2003 | ||
| 3 | Kenley Jansen | 46 | 2014 | ||
| 4 | Steve Reed | 44 | 1999 | ||
| 5 | Mariano Rivera | 43 | 2011 | ||
| 6 | Emmanuel Clase | 43 | 2022 | ||
| 7 | John Wetteland | 42 | 1998 | ||
| 8 | Jonathan Papelbon | 42 | 2010 | ||
| 9 | Mariano Rivera | 41 | 2005 | ||
| 10 | Huston Street | 41 | 2008 | ||
| 11 | Neftali Feliz | 41 | 2011 | ||
| 12 | Keith Foulke | 40 | 2004 | ||
| 13 | Mariano Rivera | 40 | 2006 | ||
| 14 | Bobby Jenks | 40 | 2008 | ||
| 15 | Francisco Rodriguez | 40 | 2008 | ||
| 16 | Rafael Soriano | 40 | 2011 | ||
| 17 | Doug Brocail | 39 | 2000 | ||
| 18 | Jason Isringhausen | 39 | 2001 | ||
| 19 | Derek Lowe | 39 | 2000 | ||
| 20 | Billy Wagner | 39 | 2003 | ||
| 21 | Jonathan Papelbon | 39 | 2008 | ||
| 22 | J.J. Putz | 39 | 2012 | ||
| 23 | Tanner Scheppers | 39 | 2014 | ||
| 24 | Cole Sulser | 39 | 2022 | ||
| 25 | Rod Beck | 38 | 1993 | ||