| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Greg Maddux | 4755.2 | |
| 2 | Randy Johnson | 4368.6 | |
| 3 | Roger Clemens | 4312.0 | |
| 4 | Mike Mussina | 4046.2 | |
| 5 | John Smoltz | 3819.5 | |
| 6 | Tom Glavine | 3816.9 | |
| 7 | Justin Verlander | 3374.7 | |
| 8 | Andy Pettitte | 3280.5 | |
| 9 | Curt Schilling | 3204.0 | |
| 10 | Tim Hudson | 3200.1 | |
| 11 | Kevin Brown | 3175.1 | |
| 12 | Zack Greinke | 3157.5 | |
| 13 | Clayton Kershaw | 3103.1 | |
| 14 | Max Scherzer | 3047.1 | |
| 15 | Roy Halladay | 2991.5 | |
| 16 | Adam Wainwright | 2855.3 | |
| 17 | Cole Hamels | 2841.7 | |
| 18 | Mark Buehrle | 2803.2 | |
| 19 | Jamie Moyer | 2797.5 | |
| 20 | Pedro Martinez | 2764.9 | |
| 21 | Jake Peavy | 2763.7 | |
| 22 | A.J. Burnett | 2752.8 | |
| 23 | Bartolo Colon | 2727.6 | |
| 24 | Felix Hernandez | 2694.0 | |
| 25 | David Wells | 2651.3 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | DOUG DRABEK | 367.0 | 1991 | ||
| 2 | ED WHITSON | 354.3 | 1991 | ||
| 3 | DENNIS MARTINEZ | 352.0 | 1991 | ||
| 4 | Zane Smith | 351.7 | 1991 | ||
| 5 | Ismael Valdes | 348.3 | 1996 | ||
| 6 | Bob Welch | 344.7 | 1991 | ||
| 7 | Roger Clemens | 344.3 | 1991 | ||
| 8 | Bruce Hurst | 341.3 | 1991 | ||
| 9 | Orel Hershiser | 340.7 | 1990 | ||
| 10 | ED WHITSON | 339.0 | 1990 | ||
| 11 | NOLAN RYAN | 338.7 | 1991 | ||
| 12 | JOSE RIJO | 338.3 | 1991 | ||
| 13 | Frank Viola | 334.3 | 1991 | ||
| 14 | Mike Boddicker | 333.0 | 1991 | ||
| 15 | Dave Stewart | 331.3 | 1991 | ||
| 16 | Mike Scott | 329.7 | 1990 | ||
| 17 | David Cone | 329.0 | 1991 | ||
| 18 | Mike Moore | 327.3 | 1990 | ||
| 19 | Bobby Witt | 326.7 | 1991 | ||
| 20 | Randy Johnson | 325.3 | 1991 | ||
| 21 | NOLAN RYAN | 322.0 | 1990 | ||
| 22 | Matt Young | 321.7 | 1991 | ||
| 23 | Bret Saberhagen | 321.0 | 1990 | ||
| 24 | Bruce Hurst | 320.7 | 1990 | ||
| 25 | John Smoltz | 319.3 | 1990 | ||