| Career - Runs | |||
| Rk | Player Name | Totals | |
| 1 | Dan Haren | 372 | |
| 2 | Jorge De La Rosa | 355 | |
| 3 | Jacob deGrom | 265 | |
| 4 | Adam Wainwright | 261 | |
| 5 | Anibal Sanchez | 257 | |
| 6 | Mike Clevinger | 227 | |
| 7 | Dustin May | 203 | |
| 8 | Chris Archer | 197 | |
| 9 | Nick Pivetta | 191 | |
| 10 | Julio Teheran | 190 | |
| 11 | Chris Young | 176 | |
| 12 | Kyle Gibson | 168 | |
| 13 | Erik Johnson | 160 | |
| 14 | Bryce Elder | 155 | |
| 15 | Francisco Rodriguez | 149 | |
| 16 | Jeff Samardzija | 148 | |
| 17 | Kenta Maeda | 143 | |
| 18 | Taijuan Walker | 142 | |
| 19 | Charlie Morton | 132 | |
| 20 | Trevor Bauer | 114 | |
| 21 | Patrick Corbin | 111 | |
| 22 | Lance McCullers | 109 | |
| 23 | Josh Beckett | 108 | |
| 24 | Brian Matusz | 105 | |
| 25 | Gio Gonzalez | 104 | |
| Single Season - Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Erik Johnson | 144 | 2014 | ||
| 2 | Dan Haren | 142 | 2015 | ||
| 3 | Jorge De La Rosa | 140 | 2015 | ||
| 4 | Charlie Morton | 130 | 2015 | ||
| 5 | Chris Archer | 123 | 2016 | ||
| 6 | Dan Haren | 118 | 2016 | ||
| 7 | Trevor Bauer | 114 | 2016 | ||
| 8 | Dan Haren | 112 | 2014 | ||
| 9 | Patrick Corbin | 111 | 2014 | ||
| 10 | Jorge de la Rosa | 110 | 2016 | ||
| 11 | Josh Beckett | 108 | 2015 | ||
| 12 | Adam Wainwright | 108 | 2022 | ||
| 13 | Jorge De La Rosa | 105 | 2014 | ||
| 14 | Kyle Gibson | 104 | 2019 | ||
| 15 | Mike Clevinger | 104 | 2020 | ||
| 16 | Gio Gonzalez | 104 | 2020 | ||
| 17 | Anibal Sanchez | 102 | 2020 | ||
| 18 | Julio Teheran | 99 | 2020 | ||
| 19 | Trevor May | 95 | 2015 | ||
| 20 | Jon Gray | 95 | 2024 | ||
| 21 | Chris Young | 92 | 2016 | ||
| 22 | Julio Teheran | 91 | 2019 | ||
| 23 | Adam Wainwright | 88 | 2021 | ||
| 24 | Justin Dunn | 88 | 2022 | ||
| 25 | Bryce Elder | 88 | 2024 | ||